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Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

BACKGROUND: Activating Gα(q) signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT(2)R) forms a rare alternative. The role of wild-type CysLT(2)R in uveal m...

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Detalles Bibliográficos
Autores principales:	Nell, Rogier J., Menger, Nino V., Versluis, Mieke, Luyten, Gregorius P. M., Verdijk, Robert M., Madigan, Michele C., Jager, Martine J., van der Velden, Pieter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885466/ https://www.ncbi.nlm.nih.gov/pubmed/33588787 http://dx.doi.org/10.1186/s12885-021-07865-x

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