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MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

BACKGROUND: Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the molecules involved. METHODS: miR-545 expression in OC tissues and cell lines was...

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Detalles Bibliográficos
Autores principales:	Zhang, Hailing, Zhang, Ke, Xu, Zhen, Chen, Zhilong, Wang, Qian, Wang, Chenyang, Cui, Jinquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885496/ https://www.ncbi.nlm.nih.gov/pubmed/33588776 http://dx.doi.org/10.1186/s12885-021-07830-8

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