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COVID-19 and cancer: A comparative case series

BACKGROUND: Cancer patients, with an incidence of more than 18 million new cases per year, may constitute a significant portion of the COVID-19 infected population. In the pandemic situation, these patients are considered highly vulnerable to infectious complications due to their immunocompromised s...

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Autores principales: Mousavi, Seied Asadollah, Rostami, Tahereh, Kiumarsi, Azadeh, Rad, Soroush, Rostami, Mohammadreza, Motamedi, Fatemeh, Gandomi-Mohammadabadi, Alireza, Mirhosseini, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885684/
https://www.ncbi.nlm.nih.gov/pubmed/33618150
http://dx.doi.org/10.1016/j.ctarc.2021.100339
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author Mousavi, Seied Asadollah
Rostami, Tahereh
Kiumarsi, Azadeh
Rad, Soroush
Rostami, Mohammadreza
Motamedi, Fatemeh
Gandomi-Mohammadabadi, Alireza
Mirhosseini, Amirhossein
author_facet Mousavi, Seied Asadollah
Rostami, Tahereh
Kiumarsi, Azadeh
Rad, Soroush
Rostami, Mohammadreza
Motamedi, Fatemeh
Gandomi-Mohammadabadi, Alireza
Mirhosseini, Amirhossein
author_sort Mousavi, Seied Asadollah
collection PubMed
description BACKGROUND: Cancer patients, with an incidence of more than 18 million new cases per year, may constitute a significant portion of the COVID-19 infected population. In the pandemic situation, these patients are considered highly vulnerable to infectious complications due to their immunocompromised state. MATERIAL & METHODS: In this retrospective case series, the documents of solid cancer patients infected by SARS-CoV-2, hospitalized in Shariati hospital between 20 February and 20 April 2020, were evaluated. The diagnosis of COVID-19 was based on laboratory-confirmed COVID-19 and/or features of chest CT scan highly suggestive for SARS-CoV-2. RESULTS: A total of 33 COVID-19-infected cancer patients were included. Mean age was 63.9 years, and 54.5% of the patients were male. LDH level was significantly higher (1487.5 ± 1392.8 vs. 932.3 ± 324.7 U/L, P-value=0.016) and also serum albumin was significantly lower in non-survivors (3.6 ± 0.5 vs. 2.9 ± 0.6 g/dL, p-value=0.03). Among 16 patients with stage IV cancer, thirteen patients died, which was significantly higher compared to stage I-III cancer patients (81.3% vs. 18.8% P-value= <0.001). In terms of developing complications, sepsis, invasive ventilation and mortality was significantly higher in patients who received cytotoxic chemotherapy within the last 14 days. CONCLUSION: In this study, we showed that the mortality rate among cancer patients affected by COVID-19 was higher than general population and this rate has a significant correlation with factors including the stage of the disease, the type of cancer, the activity of cancer and finally receiving cytotoxic chemotherapy within 14 days before diagnosis of COVID-19.
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spelling pubmed-78856842021-02-16 COVID-19 and cancer: A comparative case series Mousavi, Seied Asadollah Rostami, Tahereh Kiumarsi, Azadeh Rad, Soroush Rostami, Mohammadreza Motamedi, Fatemeh Gandomi-Mohammadabadi, Alireza Mirhosseini, Amirhossein Cancer Treat Res Commun Article BACKGROUND: Cancer patients, with an incidence of more than 18 million new cases per year, may constitute a significant portion of the COVID-19 infected population. In the pandemic situation, these patients are considered highly vulnerable to infectious complications due to their immunocompromised state. MATERIAL & METHODS: In this retrospective case series, the documents of solid cancer patients infected by SARS-CoV-2, hospitalized in Shariati hospital between 20 February and 20 April 2020, were evaluated. The diagnosis of COVID-19 was based on laboratory-confirmed COVID-19 and/or features of chest CT scan highly suggestive for SARS-CoV-2. RESULTS: A total of 33 COVID-19-infected cancer patients were included. Mean age was 63.9 years, and 54.5% of the patients were male. LDH level was significantly higher (1487.5 ± 1392.8 vs. 932.3 ± 324.7 U/L, P-value=0.016) and also serum albumin was significantly lower in non-survivors (3.6 ± 0.5 vs. 2.9 ± 0.6 g/dL, p-value=0.03). Among 16 patients with stage IV cancer, thirteen patients died, which was significantly higher compared to stage I-III cancer patients (81.3% vs. 18.8% P-value= <0.001). In terms of developing complications, sepsis, invasive ventilation and mortality was significantly higher in patients who received cytotoxic chemotherapy within the last 14 days. CONCLUSION: In this study, we showed that the mortality rate among cancer patients affected by COVID-19 was higher than general population and this rate has a significant correlation with factors including the stage of the disease, the type of cancer, the activity of cancer and finally receiving cytotoxic chemotherapy within 14 days before diagnosis of COVID-19. Published by Elsevier Ltd. 2021 2021-02-16 /pmc/articles/PMC7885684/ /pubmed/33618150 http://dx.doi.org/10.1016/j.ctarc.2021.100339 Text en © 2021 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mousavi, Seied Asadollah
Rostami, Tahereh
Kiumarsi, Azadeh
Rad, Soroush
Rostami, Mohammadreza
Motamedi, Fatemeh
Gandomi-Mohammadabadi, Alireza
Mirhosseini, Amirhossein
COVID-19 and cancer: A comparative case series
title COVID-19 and cancer: A comparative case series
title_full COVID-19 and cancer: A comparative case series
title_fullStr COVID-19 and cancer: A comparative case series
title_full_unstemmed COVID-19 and cancer: A comparative case series
title_short COVID-19 and cancer: A comparative case series
title_sort covid-19 and cancer: a comparative case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885684/
https://www.ncbi.nlm.nih.gov/pubmed/33618150
http://dx.doi.org/10.1016/j.ctarc.2021.100339
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