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Role of the Microbiome in Interstitial Lung Diseases
There are trillions of microorganisms in the human body, consisting of bacteria, viruses, fungi, and archaea; these collectively make up the microbiome. Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic target, or provide an explanation for pathophysiolog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885795/ https://www.ncbi.nlm.nih.gov/pubmed/33604346 http://dx.doi.org/10.3389/fmed.2021.595522 |
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author | Chioma, Ozioma S. Hesse, Laura E. Chapman, Austin Drake, Wonder P. |
author_facet | Chioma, Ozioma S. Hesse, Laura E. Chapman, Austin Drake, Wonder P. |
author_sort | Chioma, Ozioma S. |
collection | PubMed |
description | There are trillions of microorganisms in the human body, consisting of bacteria, viruses, fungi, and archaea; these collectively make up the microbiome. Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic target, or provide an explanation for pathophysiology in lung diseases. Studies describing the impact of the microorganisms found in the respiratory tract on lung health have been published and are discussed here in the context of interstitial lung diseases. Additionally, epidemiological and experimental evidence highlights the importance of cross-talk between the gut microbiota and the lungs, called the gut–lung axis. The gut-lung axis postulates that alterations in gut microbial communities may have a profound effect on lung disease. Dysbiosis in the microbial community of the gut is linked with changes in immune responses, homeostasis in the airways, and inflammatory conditions in the gastrointestinal tract itself. In this review, we summarize studies describing the role of the microbiome in interstitial lung disease and discuss the implications of these findings on the diagnosis and treatment of these diseases. This paper describes the impact of the microbial communities on the pathogenesis of lung diseases by assessing recent original research and identifying remaining gaps in knowledge. |
format | Online Article Text |
id | pubmed-7885795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78857952021-02-17 Role of the Microbiome in Interstitial Lung Diseases Chioma, Ozioma S. Hesse, Laura E. Chapman, Austin Drake, Wonder P. Front Med (Lausanne) Medicine There are trillions of microorganisms in the human body, consisting of bacteria, viruses, fungi, and archaea; these collectively make up the microbiome. Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic target, or provide an explanation for pathophysiology in lung diseases. Studies describing the impact of the microorganisms found in the respiratory tract on lung health have been published and are discussed here in the context of interstitial lung diseases. Additionally, epidemiological and experimental evidence highlights the importance of cross-talk between the gut microbiota and the lungs, called the gut–lung axis. The gut-lung axis postulates that alterations in gut microbial communities may have a profound effect on lung disease. Dysbiosis in the microbial community of the gut is linked with changes in immune responses, homeostasis in the airways, and inflammatory conditions in the gastrointestinal tract itself. In this review, we summarize studies describing the role of the microbiome in interstitial lung disease and discuss the implications of these findings on the diagnosis and treatment of these diseases. This paper describes the impact of the microbial communities on the pathogenesis of lung diseases by assessing recent original research and identifying remaining gaps in knowledge. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7885795/ /pubmed/33604346 http://dx.doi.org/10.3389/fmed.2021.595522 Text en Copyright © 2021 Chioma, Hesse, Chapman and Drake. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Chioma, Ozioma S. Hesse, Laura E. Chapman, Austin Drake, Wonder P. Role of the Microbiome in Interstitial Lung Diseases |
title | Role of the Microbiome in Interstitial Lung Diseases |
title_full | Role of the Microbiome in Interstitial Lung Diseases |
title_fullStr | Role of the Microbiome in Interstitial Lung Diseases |
title_full_unstemmed | Role of the Microbiome in Interstitial Lung Diseases |
title_short | Role of the Microbiome in Interstitial Lung Diseases |
title_sort | role of the microbiome in interstitial lung diseases |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885795/ https://www.ncbi.nlm.nih.gov/pubmed/33604346 http://dx.doi.org/10.3389/fmed.2021.595522 |
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