Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Detalles Bibliográficos
Autores principales: Ngabonziza, Jean Claude S, Decroo, Tom, Maniliho, Rodrigue, Habimana, Yves M, Van Deun, Armand, de Jong, Bouke C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885858/
https://www.ncbi.nlm.nih.gov/pubmed/33614819
http://dx.doi.org/10.1093/ofid/ofab034
_version_ 1783651683501342720
author Ngabonziza, Jean Claude S
Decroo, Tom
Maniliho, Rodrigue
Habimana, Yves M
Van Deun, Armand
de Jong, Bouke C
author_facet Ngabonziza, Jean Claude S
Decroo, Tom
Maniliho, Rodrigue
Habimana, Yves M
Van Deun, Armand
de Jong, Bouke C
author_sort Ngabonziza, Jean Claude S
collection PubMed
description We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.
format Online
Article
Text
id pubmed-7885858
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-78858582021-02-19 Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases Ngabonziza, Jean Claude S Decroo, Tom Maniliho, Rodrigue Habimana, Yves M Van Deun, Armand de Jong, Bouke C Open Forum Infect Dis Brief Reports We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted. Oxford University Press 2021-01-21 /pmc/articles/PMC7885858/ /pubmed/33614819 http://dx.doi.org/10.1093/ofid/ofab034 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Ngabonziza, Jean Claude S
Decroo, Tom
Maniliho, Rodrigue
Habimana, Yves M
Van Deun, Armand
de Jong, Bouke C
Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title_full Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title_fullStr Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title_full_unstemmed Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title_short Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases
title_sort low cycle threshold value in xpert mtb/rif assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885858/
https://www.ncbi.nlm.nih.gov/pubmed/33614819
http://dx.doi.org/10.1093/ofid/ofab034
work_keys_str_mv AT ngabonzizajeanclaudes lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases
AT decrootom lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases
AT manilihorodrigue lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases
AT habimanayvesm lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases
AT vandeunarmand lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases
AT dejongboukec lowcyclethresholdvalueinxpertmtbrifassaymayheraldfalsedetectionoftuberculosisandrifampicinresistanceastudyoftwocases

Ejemplares similares