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Using CRISPR to enhance T cell effector function for therapeutic applications
T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α and IL-2. Tumors possess many inhibitory mechanisms that d...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885876/ https://www.ncbi.nlm.nih.gov/pubmed/33604565 http://dx.doi.org/10.1016/j.cytox.2020.100049 |