Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

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The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and signaling responses to inflammatory ligands were assessed in pe...

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Detalles Bibliográficos
Autores principales: Feyaerts, Dorien, Hédou, Julien, Gillard, Joshua, Chen, Han, Tsai, Eileen S., Peterson, Laura S., Ando, Kazuo, Manohar, Monali, Do, Evan, Dhondalay, Gopal K.R., Fitzpatrick, Jessica, Artandi, Maja, Chang, Iris, Snow, Theo T., Chinthrajah, R. Sharon, Warren, Christopher M., Wittman, Rich, Meyerowitz, Justin G., Ganio, Edward A., Stelzer, Ina A., Han, Xiaoyuan, Verdonk, Franck, Gaudillière, Dyani K., Mukherjee, Nilanjan, Tsai, Amy S., Rumer, Kristen K., Jiang, Sizun, Valdés Ferrer, Sergio Iván, Kelly, J. Daniel, Furman, David, Aghaeepour, Nima, Angst, Martin S., Boyd, Scott D., Pinsky, Benjamin A., Nolan, Garry P., Nadeau, Kari C., Gaudillière, Brice, McIlwain, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885914/
https://www.ncbi.nlm.nih.gov/pubmed/33594362
http://dx.doi.org/10.1101/2021.02.09.430269
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