CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

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This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all...

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Detalles Bibliográficos
Autores principales: Redd, Andrew D, Nardin, Alessandra, Kared, Hassen, Bloch, Evan M, Pekosz, Andrew, Laeyendecker, Oliver, Abel, Brian, Fehlings, Michael, Quinn, Thomas C, Tobian, Aaron AR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885937/
https://www.ncbi.nlm.nih.gov/pubmed/33594378
http://dx.doi.org/10.1101/2021.02.11.21251585
Descripción
Sumario:This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

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