CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

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This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all...

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Autores principales: Redd, Andrew D, Nardin, Alessandra, Kared, Hassen, Bloch, Evan M, Pekosz, Andrew, Laeyendecker, Oliver, Abel, Brian, Fehlings, Michael, Quinn, Thomas C, Tobian, Aaron AR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885937/
https://www.ncbi.nlm.nih.gov/pubmed/33594378
http://dx.doi.org/10.1101/2021.02.11.21251585
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author Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron AR
author_facet Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron AR
author_sort Redd, Andrew D
collection PubMed
description This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.
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spelling pubmed-78859372021-02-17 CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants Redd, Andrew D Nardin, Alessandra Kared, Hassen Bloch, Evan M Pekosz, Andrew Laeyendecker, Oliver Abel, Brian Fehlings, Michael Quinn, Thomas C Tobian, Aaron AR medRxiv Article This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals(n=30) potentially maintain recognition of the major SARS-CoV-2 variants. Out of 45 mutations assessed, only one from the B.1.351 Spike overlapped with a low-prevalence CD8+ epitope, suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants. Cold Spring Harbor Laboratory 2021-02-12 /pmc/articles/PMC7885937/ /pubmed/33594378 http://dx.doi.org/10.1101/2021.02.11.21251585 Text en https://creativecommons.org/publicdomain/zero/1.0/This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license (https://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Article
Redd, Andrew D
Nardin, Alessandra
Kared, Hassen
Bloch, Evan M
Pekosz, Andrew
Laeyendecker, Oliver
Abel, Brian
Fehlings, Michael
Quinn, Thomas C
Tobian, Aaron AR
CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title_full CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title_fullStr CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title_full_unstemmed CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title_short CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
title_sort cd8+ t cell responses in covid-19 convalescent individuals target conserved epitopes from multiple prominent sars-cov-2 circulating variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885937/
https://www.ncbi.nlm.nih.gov/pubmed/33594378
http://dx.doi.org/10.1101/2021.02.11.21251585
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