Recent advances in understanding cholangiocarcinoma

The definition of cholangiocarcinoma (CCA) encompasses all tumors originating in the epithelium of the bile ducts, including the intrahepatic bile ducts (ICCA) and extrahepatic bile ducts (ECCA). The incidence of ICCA and ECCA has increased in the last few decades, and molecular advances in both ent...

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Detalles Bibliográficos
Autores principales: Uson Junior, Pedro Luiz Serrano, Arora, Mansi, Bogenberger, James M, Borad, Mitesh J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty Opinions Ltd 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886064/
https://www.ncbi.nlm.nih.gov/pubmed/33659947
http://dx.doi.org/10.12703/b/9-15
Descripción
Sumario:The definition of cholangiocarcinoma (CCA) encompasses all tumors originating in the epithelium of the bile ducts, including the intrahepatic bile ducts (ICCA) and extrahepatic bile ducts (ECCA). The incidence of ICCA and ECCA has increased in the last few decades, and molecular advances in both entities have brought understanding of their differences and allowed treatment advances aimed at personalized therapy. In this review, we discuss recent progress in the molecular landscape of CCAs, emerging treatment biomarker-guided strategies, and future insights into the management of advanced disease.

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