Recent advances in understanding cholangiocarcinoma

The definition of cholangiocarcinoma (CCA) encompasses all tumors originating in the epithelium of the bile ducts, including the intrahepatic bile ducts (ICCA) and extrahepatic bile ducts (ECCA). The incidence of ICCA and ECCA has increased in the last few decades, and molecular advances in both ent...

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Detalles Bibliográficos
Autores principales: Uson Junior, Pedro Luiz Serrano, Arora, Mansi, Bogenberger, James M, Borad, Mitesh J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty Opinions Ltd 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886064/
https://www.ncbi.nlm.nih.gov/pubmed/33659947
http://dx.doi.org/10.12703/b/9-15
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author Uson Junior, Pedro Luiz Serrano
Arora, Mansi
Bogenberger, James M
Borad, Mitesh J
author_facet Uson Junior, Pedro Luiz Serrano
Arora, Mansi
Bogenberger, James M
Borad, Mitesh J
author_sort Uson Junior, Pedro Luiz Serrano
collection PubMed
description The definition of cholangiocarcinoma (CCA) encompasses all tumors originating in the epithelium of the bile ducts, including the intrahepatic bile ducts (ICCA) and extrahepatic bile ducts (ECCA). The incidence of ICCA and ECCA has increased in the last few decades, and molecular advances in both entities have brought understanding of their differences and allowed treatment advances aimed at personalized therapy. In this review, we discuss recent progress in the molecular landscape of CCAs, emerging treatment biomarker-guided strategies, and future insights into the management of advanced disease.
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spelling pubmed-78860642021-03-02 Recent advances in understanding cholangiocarcinoma Uson Junior, Pedro Luiz Serrano Arora, Mansi Bogenberger, James M Borad, Mitesh J Fac Rev Review Article The definition of cholangiocarcinoma (CCA) encompasses all tumors originating in the epithelium of the bile ducts, including the intrahepatic bile ducts (ICCA) and extrahepatic bile ducts (ECCA). The incidence of ICCA and ECCA has increased in the last few decades, and molecular advances in both entities have brought understanding of their differences and allowed treatment advances aimed at personalized therapy. In this review, we discuss recent progress in the molecular landscape of CCAs, emerging treatment biomarker-guided strategies, and future insights into the management of advanced disease. Faculty Opinions Ltd 2020-11-19 /pmc/articles/PMC7886064/ /pubmed/33659947 http://dx.doi.org/10.12703/b/9-15 Text en Copyright: © 2020 Borad MJ et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Uson Junior, Pedro Luiz Serrano
Arora, Mansi
Bogenberger, James M
Borad, Mitesh J
Recent advances in understanding cholangiocarcinoma
title Recent advances in understanding cholangiocarcinoma
title_full Recent advances in understanding cholangiocarcinoma
title_fullStr Recent advances in understanding cholangiocarcinoma
title_full_unstemmed Recent advances in understanding cholangiocarcinoma
title_short Recent advances in understanding cholangiocarcinoma
title_sort recent advances in understanding cholangiocarcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886064/
https://www.ncbi.nlm.nih.gov/pubmed/33659947
http://dx.doi.org/10.12703/b/9-15
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