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Adaptive evolution of nontransitive fitness in yeast
A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886323/ https://www.ncbi.nlm.nih.gov/pubmed/33372653 http://dx.doi.org/10.7554/eLife.62238 |
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author | Buskirk, Sean W Rokes, Alecia B Lang, Gregory I |
author_facet | Buskirk, Sean W Rokes, Alecia B Lang, Gregory I |
author_sort | Buskirk, Sean W |
collection | PubMed |
description | A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms that are less fit compared to a distant ancestor. Here we identify a nontransitive evolutionary sequence in a 1000-generation yeast evolution experiment. We show that nontransitivity arises due to adaptation in the yeast nuclear genome combined with the stepwise deterioration of an intracellular virus, which provides an advantage over viral competitors within host cells. Extending our analysis, we find that nearly half of our ~140 populations experience multilevel selection, fixing adaptive mutations in both the nuclear and viral genomes. Our results provide a mechanistic case-study for the adaptive evolution of nontransitivity due to multilevel selection in a 1000-generation host/virus evolution experiment. |
format | Online Article Text |
id | pubmed-7886323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78863232021-02-17 Adaptive evolution of nontransitive fitness in yeast Buskirk, Sean W Rokes, Alecia B Lang, Gregory I eLife Evolutionary Biology A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms that are less fit compared to a distant ancestor. Here we identify a nontransitive evolutionary sequence in a 1000-generation yeast evolution experiment. We show that nontransitivity arises due to adaptation in the yeast nuclear genome combined with the stepwise deterioration of an intracellular virus, which provides an advantage over viral competitors within host cells. Extending our analysis, we find that nearly half of our ~140 populations experience multilevel selection, fixing adaptive mutations in both the nuclear and viral genomes. Our results provide a mechanistic case-study for the adaptive evolution of nontransitivity due to multilevel selection in a 1000-generation host/virus evolution experiment. eLife Sciences Publications, Ltd 2020-12-29 /pmc/articles/PMC7886323/ /pubmed/33372653 http://dx.doi.org/10.7554/eLife.62238 Text en © 2020, Buskirk et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Buskirk, Sean W Rokes, Alecia B Lang, Gregory I Adaptive evolution of nontransitive fitness in yeast |
title | Adaptive evolution of nontransitive fitness in yeast |
title_full | Adaptive evolution of nontransitive fitness in yeast |
title_fullStr | Adaptive evolution of nontransitive fitness in yeast |
title_full_unstemmed | Adaptive evolution of nontransitive fitness in yeast |
title_short | Adaptive evolution of nontransitive fitness in yeast |
title_sort | adaptive evolution of nontransitive fitness in yeast |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886323/ https://www.ncbi.nlm.nih.gov/pubmed/33372653 http://dx.doi.org/10.7554/eLife.62238 |
work_keys_str_mv | AT buskirkseanw adaptiveevolutionofnontransitivefitnessinyeast AT rokesaleciab adaptiveevolutionofnontransitivefitnessinyeast AT langgregoryi adaptiveevolutionofnontransitivefitnessinyeast |