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Adaptive evolution of nontransitive fitness in yeast

A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms...

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Autores principales: Buskirk, Sean W, Rokes, Alecia B, Lang, Gregory I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886323/
https://www.ncbi.nlm.nih.gov/pubmed/33372653
http://dx.doi.org/10.7554/eLife.62238
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author Buskirk, Sean W
Rokes, Alecia B
Lang, Gregory I
author_facet Buskirk, Sean W
Rokes, Alecia B
Lang, Gregory I
author_sort Buskirk, Sean W
collection PubMed
description A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms that are less fit compared to a distant ancestor. Here we identify a nontransitive evolutionary sequence in a 1000-generation yeast evolution experiment. We show that nontransitivity arises due to adaptation in the yeast nuclear genome combined with the stepwise deterioration of an intracellular virus, which provides an advantage over viral competitors within host cells. Extending our analysis, we find that nearly half of our ~140 populations experience multilevel selection, fixing adaptive mutations in both the nuclear and viral genomes. Our results provide a mechanistic case-study for the adaptive evolution of nontransitivity due to multilevel selection in a 1000-generation host/virus evolution experiment.
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spelling pubmed-78863232021-02-17 Adaptive evolution of nontransitive fitness in yeast Buskirk, Sean W Rokes, Alecia B Lang, Gregory I eLife Evolutionary Biology A common misconception is that evolution is a linear ‘march of progress’, where each organism along a line of descent is more fit than all those that came before it. Rejecting this misconception implies that evolution is nontransitive: a series of adaptive events will, on occasion, produce organisms that are less fit compared to a distant ancestor. Here we identify a nontransitive evolutionary sequence in a 1000-generation yeast evolution experiment. We show that nontransitivity arises due to adaptation in the yeast nuclear genome combined with the stepwise deterioration of an intracellular virus, which provides an advantage over viral competitors within host cells. Extending our analysis, we find that nearly half of our ~140 populations experience multilevel selection, fixing adaptive mutations in both the nuclear and viral genomes. Our results provide a mechanistic case-study for the adaptive evolution of nontransitivity due to multilevel selection in a 1000-generation host/virus evolution experiment. eLife Sciences Publications, Ltd 2020-12-29 /pmc/articles/PMC7886323/ /pubmed/33372653 http://dx.doi.org/10.7554/eLife.62238 Text en © 2020, Buskirk et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Evolutionary Biology
Buskirk, Sean W
Rokes, Alecia B
Lang, Gregory I
Adaptive evolution of nontransitive fitness in yeast
title Adaptive evolution of nontransitive fitness in yeast
title_full Adaptive evolution of nontransitive fitness in yeast
title_fullStr Adaptive evolution of nontransitive fitness in yeast
title_full_unstemmed Adaptive evolution of nontransitive fitness in yeast
title_short Adaptive evolution of nontransitive fitness in yeast
title_sort adaptive evolution of nontransitive fitness in yeast
topic Evolutionary Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886323/
https://www.ncbi.nlm.nih.gov/pubmed/33372653
http://dx.doi.org/10.7554/eLife.62238
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