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Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

During development, oligodendrocytes and Schwann cells myelinate central and peripheral nervous system axons, respectively, while motor exit point (MEP) glia are neural tube-derived, peripheral glia that myelinate axonal territory between these populations at MEP transition zones. From which specifi...

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Detalles Bibliográficos
Autores principales: Fontenas, Laura, Kucenas, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886336/
https://www.ncbi.nlm.nih.gov/pubmed/33554855
http://dx.doi.org/10.7554/eLife.64267
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author Fontenas, Laura
Kucenas, Sarah
author_facet Fontenas, Laura
Kucenas, Sarah
author_sort Fontenas, Laura
collection PubMed
description During development, oligodendrocytes and Schwann cells myelinate central and peripheral nervous system axons, respectively, while motor exit point (MEP) glia are neural tube-derived, peripheral glia that myelinate axonal territory between these populations at MEP transition zones. From which specific neural tube precursors MEP glia are specified, and how they exit the neural tube to migrate onto peripheral motor axons, remain largely unknown. Here, using zebrafish, we found that MEP glia arise from lateral floor plate precursors and require foxd3 to delaminate and exit the spinal cord. Additionally, we show that similar to Schwann cells, MEP glial development depends on axonally derived neuregulin1. Finally, our data demonstrate that overexpressing axonal cues is sufficient to generate additional MEP glia in the spinal cord. Overall, these studies provide new insight into how a novel population of hybrid, peripheral myelinating glia are generated from neural tube precursors and migrate into the periphery.
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spelling pubmed-78863362021-02-18 Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia Fontenas, Laura Kucenas, Sarah eLife Developmental Biology During development, oligodendrocytes and Schwann cells myelinate central and peripheral nervous system axons, respectively, while motor exit point (MEP) glia are neural tube-derived, peripheral glia that myelinate axonal territory between these populations at MEP transition zones. From which specific neural tube precursors MEP glia are specified, and how they exit the neural tube to migrate onto peripheral motor axons, remain largely unknown. Here, using zebrafish, we found that MEP glia arise from lateral floor plate precursors and require foxd3 to delaminate and exit the spinal cord. Additionally, we show that similar to Schwann cells, MEP glial development depends on axonally derived neuregulin1. Finally, our data demonstrate that overexpressing axonal cues is sufficient to generate additional MEP glia in the spinal cord. Overall, these studies provide new insight into how a novel population of hybrid, peripheral myelinating glia are generated from neural tube precursors and migrate into the periphery. eLife Sciences Publications, Ltd 2021-02-08 /pmc/articles/PMC7886336/ /pubmed/33554855 http://dx.doi.org/10.7554/eLife.64267 Text en © 2021, Fontenas and Kucenas http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Fontenas, Laura
Kucenas, Sarah
Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title_full Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title_fullStr Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title_full_unstemmed Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title_short Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
title_sort spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886336/
https://www.ncbi.nlm.nih.gov/pubmed/33554855
http://dx.doi.org/10.7554/eLife.64267
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