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Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression

PURPOSE: Resistance exercise improves an array of treatment-related adverse effects in men with prostate cancer; however, the minimal dosage required is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exerc...

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Autores principales: LOPEZ, PEDRO, TAAFFE, DENNIS R., NEWTON, ROBERT U., GALVÃO, DANIEL A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886340/
https://www.ncbi.nlm.nih.gov/pubmed/32890199
http://dx.doi.org/10.1249/MSS.0000000000002503
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author LOPEZ, PEDRO
TAAFFE, DENNIS R.
NEWTON, ROBERT U.
GALVÃO, DANIEL A.
author_facet LOPEZ, PEDRO
TAAFFE, DENNIS R.
NEWTON, ROBERT U.
GALVÃO, DANIEL A.
author_sort LOPEZ, PEDRO
collection PubMed
description PURPOSE: Resistance exercise improves an array of treatment-related adverse effects in men with prostate cancer; however, the minimal dosage required is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exercise components (type, duration, volume, and intensity) on body composition, physical function, muscle strength, cardiorespiratory fitness, body mass index, and prostate-specific antigen. METHODS: Using PRISMA guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases were searched. Eligible randomized controlled trials examined prostate cancer patients undertaking resistance-based exercise programs during or after treatment. Meta-analysis was undertaken when more than three studies were included. Associations between mean differences and exercise components were tested by univariate and multivariate meta-regression analysis. RESULTS: Twenty-three articles describing 21 trials and involving 1748 prostate cancer patients were included. Exercise improved fat mass (−1% in body fat and −0.6 kg in fat mass), lean mass (~0.5 kg in lean and appendicular lean mass), functional capacity (i.e., chair rise, 400-m test, 6-m fast walk, and stair climb tests), and fitness outcomes (i.e., V̇O(2peak) and muscle strength) (P = 0.040–<0.001) with no change in body mass index or prostate-specific antigen (P = 0.440–0.735). Meta-regression indicated no association between exercise type, resistance training duration, weekly volume and intensity, and primary outcomes (P = 0.075–0.965). There was a significant association between exercise intensity and chest press muscle strength (favoring moderate intensity, P = 0.012), but not in other secondary outcomes. CONCLUSION: In untrained older men with prostate cancer initiating an exercise program, lower volume at moderate to high intensity is as effective as higher volume resistance training for enhancing body composition, functional capacity, and muscle strength in the short term. A low exercise dosage may help reduce barriers to exercise and enhance adherence.
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spelling pubmed-78863402021-02-22 Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression LOPEZ, PEDRO TAAFFE, DENNIS R. NEWTON, ROBERT U. GALVÃO, DANIEL A. Med Sci Sports Exerc Clinical Sciences PURPOSE: Resistance exercise improves an array of treatment-related adverse effects in men with prostate cancer; however, the minimal dosage required is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exercise components (type, duration, volume, and intensity) on body composition, physical function, muscle strength, cardiorespiratory fitness, body mass index, and prostate-specific antigen. METHODS: Using PRISMA guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases were searched. Eligible randomized controlled trials examined prostate cancer patients undertaking resistance-based exercise programs during or after treatment. Meta-analysis was undertaken when more than three studies were included. Associations between mean differences and exercise components were tested by univariate and multivariate meta-regression analysis. RESULTS: Twenty-three articles describing 21 trials and involving 1748 prostate cancer patients were included. Exercise improved fat mass (−1% in body fat and −0.6 kg in fat mass), lean mass (~0.5 kg in lean and appendicular lean mass), functional capacity (i.e., chair rise, 400-m test, 6-m fast walk, and stair climb tests), and fitness outcomes (i.e., V̇O(2peak) and muscle strength) (P = 0.040–<0.001) with no change in body mass index or prostate-specific antigen (P = 0.440–0.735). Meta-regression indicated no association between exercise type, resistance training duration, weekly volume and intensity, and primary outcomes (P = 0.075–0.965). There was a significant association between exercise intensity and chest press muscle strength (favoring moderate intensity, P = 0.012), but not in other secondary outcomes. CONCLUSION: In untrained older men with prostate cancer initiating an exercise program, lower volume at moderate to high intensity is as effective as higher volume resistance training for enhancing body composition, functional capacity, and muscle strength in the short term. A low exercise dosage may help reduce barriers to exercise and enhance adherence. Lippincott Williams & Wilkins 2021-03 2020-09-04 /pmc/articles/PMC7886340/ /pubmed/32890199 http://dx.doi.org/10.1249/MSS.0000000000002503 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Clinical Sciences
LOPEZ, PEDRO
TAAFFE, DENNIS R.
NEWTON, ROBERT U.
GALVÃO, DANIEL A.
Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title_full Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title_fullStr Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title_full_unstemmed Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title_short Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression
title_sort resistance exercise dosage in men with prostate cancer: systematic review, meta-analysis, and meta-regression
topic Clinical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886340/
https://www.ncbi.nlm.nih.gov/pubmed/32890199
http://dx.doi.org/10.1249/MSS.0000000000002503
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