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Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey

We had earlier reported about the increase in the prevalence of atrial fibrillation (AF) among residents in the evacuation zone of Fukushima Prefecture after the Great East Japan Earthquake. In the present investigation, we explored the association between the prevalence of AF and white blood cell (...

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Autores principales: Suzuki, Hitoshi, Ohira, Tetsuya, Takeishi, Yasuchika, Sakai, Akira, Hosoya, Mitsuaki, Yasumura, Seiji, Kawasaki, Yukihiko, Takahashi, Atsushi, Nakano, Hironori, Kamiya, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886431/
https://www.ncbi.nlm.nih.gov/pubmed/33578521
http://dx.doi.org/10.1097/MD.0000000000024177
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author Suzuki, Hitoshi
Ohira, Tetsuya
Takeishi, Yasuchika
Sakai, Akira
Hosoya, Mitsuaki
Yasumura, Seiji
Kawasaki, Yukihiko
Takahashi, Atsushi
Nakano, Hironori
Kamiya, Kenji
author_facet Suzuki, Hitoshi
Ohira, Tetsuya
Takeishi, Yasuchika
Sakai, Akira
Hosoya, Mitsuaki
Yasumura, Seiji
Kawasaki, Yukihiko
Takahashi, Atsushi
Nakano, Hironori
Kamiya, Kenji
author_sort Suzuki, Hitoshi
collection PubMed
description We had earlier reported about the increase in the prevalence of atrial fibrillation (AF) among residents in the evacuation zone of Fukushima Prefecture after the Great East Japan Earthquake. In the present investigation, we explored the association between the prevalence of AF and white blood cell (WBC) count after the earthquake through an observational cross-sectional study. A total of 14,800 participants (6427 men and 8373 women) were included in the Fukushima Health Management Survey. For the present study, 12-lead electrocardiogram tracings and the WBC count and its subtypes were obtained and analyzed. The odds ratios (ORs) of AF after the earthquake and the 95% confidence intervals (CIs) for one standard deviation of differential WBC count were calculated after adjustments for age and other potential confounding factors using the logistic regression model. Our results revealed a prevalence of AF of 1.8% (269 participants) after the earthquake. Monocyte count and neutrophil/lymphocyte ratio exhibited a significant association with the prevalence of AF in the multivariable-adjusted model. The adjusted ORs of monocyte count and neutrophil/lymphocyte ratio for AF were 1.21 (95% CI, 1.05–1.40, P = .01) and 1.22 (95% CI, 1.01–1.44, P < .05), respectively. The prevalence of AF was associated with increased monocyte count and neutrophil/lymphocyte ratio among residents in the evacuation zone in Fukushima Prefecture, suggesting that inflammation and psychological stress could be important factors mediating the development of AF after the earthquake.
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spelling pubmed-78864312021-02-17 Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey Suzuki, Hitoshi Ohira, Tetsuya Takeishi, Yasuchika Sakai, Akira Hosoya, Mitsuaki Yasumura, Seiji Kawasaki, Yukihiko Takahashi, Atsushi Nakano, Hironori Kamiya, Kenji Medicine (Baltimore) 4400 We had earlier reported about the increase in the prevalence of atrial fibrillation (AF) among residents in the evacuation zone of Fukushima Prefecture after the Great East Japan Earthquake. In the present investigation, we explored the association between the prevalence of AF and white blood cell (WBC) count after the earthquake through an observational cross-sectional study. A total of 14,800 participants (6427 men and 8373 women) were included in the Fukushima Health Management Survey. For the present study, 12-lead electrocardiogram tracings and the WBC count and its subtypes were obtained and analyzed. The odds ratios (ORs) of AF after the earthquake and the 95% confidence intervals (CIs) for one standard deviation of differential WBC count were calculated after adjustments for age and other potential confounding factors using the logistic regression model. Our results revealed a prevalence of AF of 1.8% (269 participants) after the earthquake. Monocyte count and neutrophil/lymphocyte ratio exhibited a significant association with the prevalence of AF in the multivariable-adjusted model. The adjusted ORs of monocyte count and neutrophil/lymphocyte ratio for AF were 1.21 (95% CI, 1.05–1.40, P = .01) and 1.22 (95% CI, 1.01–1.44, P < .05), respectively. The prevalence of AF was associated with increased monocyte count and neutrophil/lymphocyte ratio among residents in the evacuation zone in Fukushima Prefecture, suggesting that inflammation and psychological stress could be important factors mediating the development of AF after the earthquake. Lippincott Williams & Wilkins 2021-02-12 /pmc/articles/PMC7886431/ /pubmed/33578521 http://dx.doi.org/10.1097/MD.0000000000024177 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4400
Suzuki, Hitoshi
Ohira, Tetsuya
Takeishi, Yasuchika
Sakai, Akira
Hosoya, Mitsuaki
Yasumura, Seiji
Kawasaki, Yukihiko
Takahashi, Atsushi
Nakano, Hironori
Kamiya, Kenji
Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title_full Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title_fullStr Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title_full_unstemmed Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title_short Association between atrial fibrillation and white blood cell count after the Great East Japan Earthquake: An observational study from the Fukushima Health Management Survey
title_sort association between atrial fibrillation and white blood cell count after the great east japan earthquake: an observational study from the fukushima health management survey
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886431/
https://www.ncbi.nlm.nih.gov/pubmed/33578521
http://dx.doi.org/10.1097/MD.0000000000024177
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