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Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis

BACKGROUND: Diabetes refers to any group of metabolic diseases characterized by high blood sugar and generally thought to be caused by insufficient production of insulin, impaired response to insulin. Globally, patients with type 2 diabetes account for more than 85% of the total diabetic patients, a...

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Autores principales: Guo, Ying, Sun, Jianfeng, Zhang, Renyan, Yang, Peng, Zhang, Sanyin, Wu, Zhipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886461/
https://www.ncbi.nlm.nih.gov/pubmed/33578512
http://dx.doi.org/10.1097/MD.0000000000023843
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author Guo, Ying
Sun, Jianfeng
Zhang, Renyan
Yang, Peng
Zhang, Sanyin
Wu, Zhipeng
author_facet Guo, Ying
Sun, Jianfeng
Zhang, Renyan
Yang, Peng
Zhang, Sanyin
Wu, Zhipeng
author_sort Guo, Ying
collection PubMed
description BACKGROUND: Diabetes refers to any group of metabolic diseases characterized by high blood sugar and generally thought to be caused by insufficient production of insulin, impaired response to insulin. Globally, patients with type 2 diabetes account for more than 85% of the total diabetic patients, and due to factors, such as obesity, aging, environment and lifestyle, the incidence of diabetes is rising. Salvia miltiorrhiza (SM) is a medicine used to treat diabetes in China. In recent years, it has been reported that SM has the effect of improving type 2 diabetes. However, there is no systematic review of its efficacy and safety yet. Therefore, we propose a systematic review to evaluate the efficacy and safety of SM for T2D. METHODS: Six databases will be searched: China National Knowledge Infrastructure (CNKI), China Biological Medicine (CBM), China Scientific Journals Database (CSJD), Wanfang database, PubMed, and EMBASE. The information is searched from January 2010 to July 2020. Languages are limited to English and Chinese. The primary outcomes include 2 hour plasma glucose, fasting plasma glucose, hemoglobin A1c, homeostasis model assessment of insulin resistance, and fasting plasma insulin. The secondary outcomes include clinical efficacy and adverse events. RESULTS: This systematic review will evaluate the efficacy and safety of Salvia miltiorrhiza in the treatment of type 2 diabetes. CONCLUSION: This systematic review provides evidence as to whether Salvia miltiorrhiza is effective and safe for type 2 diabetes. ETHICS: Ethical approval is not necessary as this protocol is only for systematic review and does not involve in privacy data or an animal experiment. SYSTEMATIC REVIEW REGISTRATION: INPLASY2020110046.
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spelling pubmed-78864612021-02-17 Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis Guo, Ying Sun, Jianfeng Zhang, Renyan Yang, Peng Zhang, Sanyin Wu, Zhipeng Medicine (Baltimore) 3800 BACKGROUND: Diabetes refers to any group of metabolic diseases characterized by high blood sugar and generally thought to be caused by insufficient production of insulin, impaired response to insulin. Globally, patients with type 2 diabetes account for more than 85% of the total diabetic patients, and due to factors, such as obesity, aging, environment and lifestyle, the incidence of diabetes is rising. Salvia miltiorrhiza (SM) is a medicine used to treat diabetes in China. In recent years, it has been reported that SM has the effect of improving type 2 diabetes. However, there is no systematic review of its efficacy and safety yet. Therefore, we propose a systematic review to evaluate the efficacy and safety of SM for T2D. METHODS: Six databases will be searched: China National Knowledge Infrastructure (CNKI), China Biological Medicine (CBM), China Scientific Journals Database (CSJD), Wanfang database, PubMed, and EMBASE. The information is searched from January 2010 to July 2020. Languages are limited to English and Chinese. The primary outcomes include 2 hour plasma glucose, fasting plasma glucose, hemoglobin A1c, homeostasis model assessment of insulin resistance, and fasting plasma insulin. The secondary outcomes include clinical efficacy and adverse events. RESULTS: This systematic review will evaluate the efficacy and safety of Salvia miltiorrhiza in the treatment of type 2 diabetes. CONCLUSION: This systematic review provides evidence as to whether Salvia miltiorrhiza is effective and safe for type 2 diabetes. ETHICS: Ethical approval is not necessary as this protocol is only for systematic review and does not involve in privacy data or an animal experiment. SYSTEMATIC REVIEW REGISTRATION: INPLASY2020110046. Lippincott Williams & Wilkins 2021-02-12 /pmc/articles/PMC7886461/ /pubmed/33578512 http://dx.doi.org/10.1097/MD.0000000000023843 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3800
Guo, Ying
Sun, Jianfeng
Zhang, Renyan
Yang, Peng
Zhang, Sanyin
Wu, Zhipeng
Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title_full Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title_fullStr Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title_full_unstemmed Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title_short Salvia miltiorrhiza improves type 2 diabetes: A protocol for systematic review and meta-analysis
title_sort salvia miltiorrhiza improves type 2 diabetes: a protocol for systematic review and meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886461/
https://www.ncbi.nlm.nih.gov/pubmed/33578512
http://dx.doi.org/10.1097/MD.0000000000023843
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