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Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition
Given its excellent performance against the pathogens, UV disinfection has been applied broadly in different fields. However, only limited studies have comprehensively investigated the response of bacteria surviving UV irradiation to the environmental antibiotic stress. Here, we investigated the ant...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886673/ https://www.ncbi.nlm.nih.gov/pubmed/33613479 http://dx.doi.org/10.3389/fmicb.2021.604245 |
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author | Li, Hai-bei Hou, Ai-ming Chen, Tian-jiao Yang, Dong Chen, Zheng-shan Shen, Zhi-qiang Qiu, Zhi-gang Yin, Jing Yang, Zhong-wei Shi, Dan-yang Wang, Hua-ran Li, Jun-wen Jin, Min |
author_facet | Li, Hai-bei Hou, Ai-ming Chen, Tian-jiao Yang, Dong Chen, Zheng-shan Shen, Zhi-qiang Qiu, Zhi-gang Yin, Jing Yang, Zhong-wei Shi, Dan-yang Wang, Hua-ran Li, Jun-wen Jin, Min |
author_sort | Li, Hai-bei |
collection | PubMed |
description | Given its excellent performance against the pathogens, UV disinfection has been applied broadly in different fields. However, only limited studies have comprehensively investigated the response of bacteria surviving UV irradiation to the environmental antibiotic stress. Here, we investigated the antibiotic susceptibility of Pseudomonas aeruginosa suffering from the UV irradiation. Our results revealed that UV exposure may decrease the susceptibility to tetracycline, ciprofloxacin, and polymyxin B in the survival P. aeruginosa. Mechanistically, UV exposure causes oxidative stress in P. aeruginosa and consequently induces dysregulation of genes contributed to the related antibiotic resistance genes. These results revealed that the insufficient ultraviolet radiation dose may result in the decreased antibiotic susceptibility in the pathogens, thus posing potential threats to the environment and human health. |
format | Online Article Text |
id | pubmed-7886673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78866732021-02-18 Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition Li, Hai-bei Hou, Ai-ming Chen, Tian-jiao Yang, Dong Chen, Zheng-shan Shen, Zhi-qiang Qiu, Zhi-gang Yin, Jing Yang, Zhong-wei Shi, Dan-yang Wang, Hua-ran Li, Jun-wen Jin, Min Front Microbiol Microbiology Given its excellent performance against the pathogens, UV disinfection has been applied broadly in different fields. However, only limited studies have comprehensively investigated the response of bacteria surviving UV irradiation to the environmental antibiotic stress. Here, we investigated the antibiotic susceptibility of Pseudomonas aeruginosa suffering from the UV irradiation. Our results revealed that UV exposure may decrease the susceptibility to tetracycline, ciprofloxacin, and polymyxin B in the survival P. aeruginosa. Mechanistically, UV exposure causes oxidative stress in P. aeruginosa and consequently induces dysregulation of genes contributed to the related antibiotic resistance genes. These results revealed that the insufficient ultraviolet radiation dose may result in the decreased antibiotic susceptibility in the pathogens, thus posing potential threats to the environment and human health. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7886673/ /pubmed/33613479 http://dx.doi.org/10.3389/fmicb.2021.604245 Text en Copyright © 2021 Li, Hou, Chen, Yang, Chen, Shen, Qiu, Yin, Yang, Shi, Wang, Li and Jin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Li, Hai-bei Hou, Ai-ming Chen, Tian-jiao Yang, Dong Chen, Zheng-shan Shen, Zhi-qiang Qiu, Zhi-gang Yin, Jing Yang, Zhong-wei Shi, Dan-yang Wang, Hua-ran Li, Jun-wen Jin, Min Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title | Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title_full | Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title_fullStr | Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title_full_unstemmed | Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title_short | Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa Surviving UV Irradition |
title_sort | decreased antibiotic susceptibility in pseudomonas aeruginosa surviving uv irradition |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886673/ https://www.ncbi.nlm.nih.gov/pubmed/33613479 http://dx.doi.org/10.3389/fmicb.2021.604245 |
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