Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such a...

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Autores principales: Jog, Neelakshi R., James, Judith A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886683/
https://www.ncbi.nlm.nih.gov/pubmed/33613559
http://dx.doi.org/10.3389/fimmu.2020.623944
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author Jog, Neelakshi R.
James, Judith A.
author_facet Jog, Neelakshi R.
James, Judith A.
author_sort Jog, Neelakshi R.
collection PubMed
description Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.
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spelling pubmed-78866832021-02-18 Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus Jog, Neelakshi R. James, Judith A. Front Immunol Immunology Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren’s syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7886683/ /pubmed/33613559 http://dx.doi.org/10.3389/fimmu.2020.623944 Text en Copyright © 2021 Jog and James http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jog, Neelakshi R.
James, Judith A.
Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title_full Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title_fullStr Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title_full_unstemmed Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title_short Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus
title_sort epstein barr virus and autoimmune responses in systemic lupus erythematosus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886683/
https://www.ncbi.nlm.nih.gov/pubmed/33613559
http://dx.doi.org/10.3389/fimmu.2020.623944
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