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Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study

BACKGROUND AND PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpa...

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Autores principales: Ma, Qiuyue, Yang, Fude, Ma, Botao, Jing, Wenzhan, Liu, Jue, Guo, Moning, Li, Juan, Wang, Zhiren, Liu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886739/
https://www.ncbi.nlm.nih.gov/pubmed/33512644
http://dx.doi.org/10.1007/s12072-020-10132-z
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author Ma, Qiuyue
Yang, Fude
Ma, Botao
Jing, Wenzhan
Liu, Jue
Guo, Moning
Li, Juan
Wang, Zhiren
Liu, Min
author_facet Ma, Qiuyue
Yang, Fude
Ma, Botao
Jing, Wenzhan
Liu, Jue
Guo, Moning
Li, Juan
Wang, Zhiren
Liu, Min
author_sort Ma, Qiuyue
collection PubMed
description BACKGROUND AND PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpatients in Beijing, China. METHODS: In this observational study, we included 66,273 mental disorder inpatients between 2014 and 2018, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Data were obtained from electronic health records of 19 specialized psychiatric hospitals in Beijing. NAFLD was defined by ICD-10 code, excluding other causes of liver disease. We calculated the overall and annual prevalence rates of NAFLD from 2014 to 2018, and compared NAFLD prevalence between sexes, age groups, mental disorders types, antipsychotics use, and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Subgroup analysis was performed in different mental disorder types. RESULTS: The prevalence of NAFLD was 17.63% (95% CI 17.34–17.92%) in mental disorder inpatients, increasing from 16.88% in 2014 to 19.07% in 2018. The NAFLD prevalence in participants with schizophrenia (22.44%) was higher than that in participants with bipolar disorder (17.89%), depressive disorder (12.62%), and other mental disorders (12.99%). Women had similar or even higher NAFLD prevalence than men after 50 years. Men, 50–59 years (aOR = 1.71), schizophrenia (aOR = 1.56), bipolar disorder (aOR = 1.47), antipsychotics use (aOR = 1.46), hypertension (aOR = 1.50), diabetes (aOR = 1.83), dyslipidemia (aOR = 2.50) were risk factors for NAFLD in mental disorder inpatients. CONCLUSION: NAFLD was common among Chinese mental disorder inpatients, and increased over years. The prevalence of NAFLD was higher among men, old women, inpatients with schizophrenia, bipolar disorder, antipsychotics, hypertension, diabetes, and dyslipidemia. Fatty liver disease among mental disorder population warrants the attention of psychiatric specialists and health policy-makers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12072-020-10132-z.
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spelling pubmed-78867392021-03-03 Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study Ma, Qiuyue Yang, Fude Ma, Botao Jing, Wenzhan Liu, Jue Guo, Moning Li, Juan Wang, Zhiren Liu, Min Hepatol Int Original Article BACKGROUND AND PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpatients in Beijing, China. METHODS: In this observational study, we included 66,273 mental disorder inpatients between 2014 and 2018, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Data were obtained from electronic health records of 19 specialized psychiatric hospitals in Beijing. NAFLD was defined by ICD-10 code, excluding other causes of liver disease. We calculated the overall and annual prevalence rates of NAFLD from 2014 to 2018, and compared NAFLD prevalence between sexes, age groups, mental disorders types, antipsychotics use, and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Subgroup analysis was performed in different mental disorder types. RESULTS: The prevalence of NAFLD was 17.63% (95% CI 17.34–17.92%) in mental disorder inpatients, increasing from 16.88% in 2014 to 19.07% in 2018. The NAFLD prevalence in participants with schizophrenia (22.44%) was higher than that in participants with bipolar disorder (17.89%), depressive disorder (12.62%), and other mental disorders (12.99%). Women had similar or even higher NAFLD prevalence than men after 50 years. Men, 50–59 years (aOR = 1.71), schizophrenia (aOR = 1.56), bipolar disorder (aOR = 1.47), antipsychotics use (aOR = 1.46), hypertension (aOR = 1.50), diabetes (aOR = 1.83), dyslipidemia (aOR = 2.50) were risk factors for NAFLD in mental disorder inpatients. CONCLUSION: NAFLD was common among Chinese mental disorder inpatients, and increased over years. The prevalence of NAFLD was higher among men, old women, inpatients with schizophrenia, bipolar disorder, antipsychotics, hypertension, diabetes, and dyslipidemia. Fatty liver disease among mental disorder population warrants the attention of psychiatric specialists and health policy-makers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12072-020-10132-z. Springer India 2021-01-29 /pmc/articles/PMC7886739/ /pubmed/33512644 http://dx.doi.org/10.1007/s12072-020-10132-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Ma, Qiuyue
Yang, Fude
Ma, Botao
Jing, Wenzhan
Liu, Jue
Guo, Moning
Li, Juan
Wang, Zhiren
Liu, Min
Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title_full Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title_fullStr Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title_full_unstemmed Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title_short Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
title_sort prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in china: an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886739/
https://www.ncbi.nlm.nih.gov/pubmed/33512644
http://dx.doi.org/10.1007/s12072-020-10132-z
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