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Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation

Historically, the health benefits and immunomodulatory potential of medicinal herbs have been considered an intrinsic quality of the herb itself. We have hypothesized that the health benefits of medicinal herbs may be partially due to their prebiotic potential that alter gut microbiota leading to ch...

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Autores principales: Peterson, Christine T., Iablokov, Stanislav N., Uchitel, Sasha, Chopra, Deepak, Perez-Santiago, Josue, Rodionov, Dmitry A., Peterson, Scott N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886795/
https://www.ncbi.nlm.nih.gov/pubmed/33613632
http://dx.doi.org/10.3389/fgene.2021.584197
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author Peterson, Christine T.
Iablokov, Stanislav N.
Uchitel, Sasha
Chopra, Deepak
Perez-Santiago, Josue
Rodionov, Dmitry A.
Peterson, Scott N.
author_facet Peterson, Christine T.
Iablokov, Stanislav N.
Uchitel, Sasha
Chopra, Deepak
Perez-Santiago, Josue
Rodionov, Dmitry A.
Peterson, Scott N.
author_sort Peterson, Christine T.
collection PubMed
description Historically, the health benefits and immunomodulatory potential of medicinal herbs have been considered an intrinsic quality of the herb itself. We have hypothesized that the health benefits of medicinal herbs may be partially due to their prebiotic potential that alter gut microbiota leading to changes in short chain fatty acids and vitamin production or biotransformation of herb encoded molecules and secondary metabolites. Accumulating studies emphasize the relationship between the gut microbiota and host immune function. While largely unknown, these interactions are mediated by secreted microbial products that activate or repress a variety of immune cell types. Here we evaluated the effect of immunomodulatory, medicinal Ayurvedic herbs on gut microbiota in vitro using 16S rRNA sequencing to assess changes in community composition and functional potential. All immunomodulatory herbs displayed substantial prebiotic potential, targeting unique taxonomic groups. Application of genome reconstruction and analysis of biosynthetic capacity of herb selected communities suggests that many of the 11 herbs tested altered the community metabolism as the result of differential glycan harvest and sugar utilization and secreted products including multiple vitamins, butyrate, and propionate that may impact host physiology and immune function. Taken together, these results provide a useful framework for the further evaluation of these immunomodulatory herbs in vivo to maintain immune homeostasis or achieve desired regulation of immune components in the context of disease.
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spelling pubmed-78867952021-02-18 Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation Peterson, Christine T. Iablokov, Stanislav N. Uchitel, Sasha Chopra, Deepak Perez-Santiago, Josue Rodionov, Dmitry A. Peterson, Scott N. Front Genet Genetics Historically, the health benefits and immunomodulatory potential of medicinal herbs have been considered an intrinsic quality of the herb itself. We have hypothesized that the health benefits of medicinal herbs may be partially due to their prebiotic potential that alter gut microbiota leading to changes in short chain fatty acids and vitamin production or biotransformation of herb encoded molecules and secondary metabolites. Accumulating studies emphasize the relationship between the gut microbiota and host immune function. While largely unknown, these interactions are mediated by secreted microbial products that activate or repress a variety of immune cell types. Here we evaluated the effect of immunomodulatory, medicinal Ayurvedic herbs on gut microbiota in vitro using 16S rRNA sequencing to assess changes in community composition and functional potential. All immunomodulatory herbs displayed substantial prebiotic potential, targeting unique taxonomic groups. Application of genome reconstruction and analysis of biosynthetic capacity of herb selected communities suggests that many of the 11 herbs tested altered the community metabolism as the result of differential glycan harvest and sugar utilization and secreted products including multiple vitamins, butyrate, and propionate that may impact host physiology and immune function. Taken together, these results provide a useful framework for the further evaluation of these immunomodulatory herbs in vivo to maintain immune homeostasis or achieve desired regulation of immune components in the context of disease. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7886795/ /pubmed/33613632 http://dx.doi.org/10.3389/fgene.2021.584197 Text en Copyright © 2021 Peterson, Iablokov, Uchitel, Chopra, Perez-Santiago, Rodionov and Peterson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Peterson, Christine T.
Iablokov, Stanislav N.
Uchitel, Sasha
Chopra, Deepak
Perez-Santiago, Josue
Rodionov, Dmitry A.
Peterson, Scott N.
Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title_full Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title_fullStr Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title_full_unstemmed Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title_short Community Metabolic Interactions, Vitamin Production and Prebiotic Potential of Medicinal Herbs Used for Immunomodulation
title_sort community metabolic interactions, vitamin production and prebiotic potential of medicinal herbs used for immunomodulation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886795/
https://www.ncbi.nlm.nih.gov/pubmed/33613632
http://dx.doi.org/10.3389/fgene.2021.584197
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