Downregulation of Soluble Guanylate Cyclase and Protein Kinase G With Upregulated ROCK2 in the Pulmonary Artery Leads to Thromboxane A2 Sensitization in Monocrotaline-Induced Pulmonary Hypertensive Rats

Thromboxane A2 (TXA(2)) promotes various physiological responses including pulmonary artery (PA) contraction, and pathophysiological implications have been suggested in cardiovascular diseases including pulmonary hypertension. Here, we investigated the role of TXA(2) receptor (TP)-mediated signaling...

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Detalles Bibliográficos
Autores principales: Cho, Suhan, Namgoong, Hyun, Kim, Hae Jin, Vorn, Rany, Yoo, Hae Young, Kim, Sung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886809/
https://www.ncbi.nlm.nih.gov/pubmed/33613315
http://dx.doi.org/10.3389/fphys.2021.624967

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