‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects

Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathwa...

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Detalles Bibliográficos
Autores principales: Schmidt, Martin C., O’Donnell, Allyson F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886833/
https://www.ncbi.nlm.nih.gov/pubmed/33136227
http://dx.doi.org/10.1007/s00294-020-01122-7
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author Schmidt, Martin C.
O’Donnell, Allyson F.
author_facet Schmidt, Martin C.
O’Donnell, Allyson F.
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description Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment.
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spelling pubmed-78868332021-03-03 ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects Schmidt, Martin C. O’Donnell, Allyson F. Curr Genet Mini-Review Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment. Springer Berlin Heidelberg 2020-11-02 2021 /pmc/articles/PMC7886833/ /pubmed/33136227 http://dx.doi.org/10.1007/s00294-020-01122-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Mini-Review
Schmidt, Martin C.
O’Donnell, Allyson F.
‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title_full ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title_fullStr ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title_full_unstemmed ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title_short ‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
title_sort ‘sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886833/
https://www.ncbi.nlm.nih.gov/pubmed/33136227
http://dx.doi.org/10.1007/s00294-020-01122-7
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