A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

During the cancerous transformation of normal hepatocytes into hepatocellular carcinoma (HCC), the enzyme catalyzing the first rate-limiting step of glycolysis, namely the glucokinase (GCK), is replaced by the higher affinity isoenzyme, hexokinase 2 (HK2). Here, we show that in HCC tumors the highes...

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Detalles Bibliográficos
Autores principales: Perrin-Cocon, Laure, Vidalain, Pierre-Olivier, Jacquemin, Clémence, Aublin-Gex, Anne, Olmstead, Keedrian, Panthu, Baptiste, Rautureau, Gilles Jeans Philippe, André, Patrice, Nyczka, Piotr, Hütt, Marc-Thorsten, Amoedo, Nivea, Rossignol, Rodrigue, Filipp, Fabian Volker, Lotteau, Vincent, Diaz, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886870/
https://www.ncbi.nlm.nih.gov/pubmed/33594203
http://dx.doi.org/10.1038/s42003-021-01749-3

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