ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

Recurring chromosomal translocation t(10;17)(p15;q21) present in a subset of human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed ZMYND11-MBTD1 (ZM); however, its function remains undetermined. Here, we show that ZM confers primary murine hematopoietic stem/progenitor c...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jie, Galbo, Phillip M., Gong, Weida, Storey, Aaron J., Tsai, Yi-Hsuan, Yu, Xufen, Ahn, Jeong Hyun, Guo, Yiran, Mackintosh, Samuel G., Edmondson, Ricky D., Byrum, Stephanie D., Farrar, Jason E., He, Shenghui, Cai, Ling, Jin, Jian, Tackett, Alan J., Zheng, Deyou, Wang, Gang Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886901/
https://www.ncbi.nlm.nih.gov/pubmed/33594072
http://dx.doi.org/10.1038/s41467-021-21357-3

Ejemplares similares

Ejemplares similares