Molecular Mechanisms of MYCN Dysregulation in Cancers

MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is exp...

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Autores principales: Liu, Ruochen, Shi, Pengfei, Wang, Zhongze, Yuan, Chaoyu, Cui, Hongjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886978/
https://www.ncbi.nlm.nih.gov/pubmed/33614505
http://dx.doi.org/10.3389/fonc.2020.625332
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author Liu, Ruochen
Shi, Pengfei
Wang, Zhongze
Yuan, Chaoyu
Cui, Hongjuan
author_facet Liu, Ruochen
Shi, Pengfei
Wang, Zhongze
Yuan, Chaoyu
Cui, Hongjuan
author_sort Liu, Ruochen
collection PubMed
description MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is expanded to multiple neuronal and nonneuronal tumors. Direct targeting N-MYC remains challenge due to its “undruggable” features. Therefore, alternative therapeutic approaches for targeting MYCN-driven tumors have been focused on the disruption of transcription, translation, protein stability as well as synthetic lethality of MYCN. In this review, we summarize the latest advances in understanding the molecular mechanisms of MYCN dysregulation in cancers.
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spelling pubmed-78869782021-02-18 Molecular Mechanisms of MYCN Dysregulation in Cancers Liu, Ruochen Shi, Pengfei Wang, Zhongze Yuan, Chaoyu Cui, Hongjuan Front Oncol Oncology MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is expanded to multiple neuronal and nonneuronal tumors. Direct targeting N-MYC remains challenge due to its “undruggable” features. Therefore, alternative therapeutic approaches for targeting MYCN-driven tumors have been focused on the disruption of transcription, translation, protein stability as well as synthetic lethality of MYCN. In this review, we summarize the latest advances in understanding the molecular mechanisms of MYCN dysregulation in cancers. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7886978/ /pubmed/33614505 http://dx.doi.org/10.3389/fonc.2020.625332 Text en Copyright © 2021 Liu, Shi, Wang, Yuan and Cui http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Ruochen
Shi, Pengfei
Wang, Zhongze
Yuan, Chaoyu
Cui, Hongjuan
Molecular Mechanisms of MYCN Dysregulation in Cancers
title Molecular Mechanisms of MYCN Dysregulation in Cancers
title_full Molecular Mechanisms of MYCN Dysregulation in Cancers
title_fullStr Molecular Mechanisms of MYCN Dysregulation in Cancers
title_full_unstemmed Molecular Mechanisms of MYCN Dysregulation in Cancers
title_short Molecular Mechanisms of MYCN Dysregulation in Cancers
title_sort molecular mechanisms of mycn dysregulation in cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886978/
https://www.ncbi.nlm.nih.gov/pubmed/33614505
http://dx.doi.org/10.3389/fonc.2020.625332
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