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Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China

Hemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus (HV) infection, and is prevalent across Europe and Asia (mainly China). The genetic variation and wide host range of the HV family may lead to vaccine failure. In this study, we analyzed the gene sequences of HV isolated from diffe...

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Autores principales: Wang, Qiuwei, Yue, Ming, Yao, Pingping, Zhu, Changqiang, Ai, Lele, Hu, Dan, Zhang, Bin, Yang, Zhangnv, Yang, Xiaohong, Luo, Fan, Wang, Chunhui, Hou, Wei, Tan, Weilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886990/
https://www.ncbi.nlm.nih.gov/pubmed/33614521
http://dx.doi.org/10.3389/fcimb.2020.584814
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author Wang, Qiuwei
Yue, Ming
Yao, Pingping
Zhu, Changqiang
Ai, Lele
Hu, Dan
Zhang, Bin
Yang, Zhangnv
Yang, Xiaohong
Luo, Fan
Wang, Chunhui
Hou, Wei
Tan, Weilong
author_facet Wang, Qiuwei
Yue, Ming
Yao, Pingping
Zhu, Changqiang
Ai, Lele
Hu, Dan
Zhang, Bin
Yang, Zhangnv
Yang, Xiaohong
Luo, Fan
Wang, Chunhui
Hou, Wei
Tan, Weilong
author_sort Wang, Qiuwei
collection PubMed
description Hemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus (HV) infection, and is prevalent across Europe and Asia (mainly China). The genetic variation and wide host range of the HV family may lead to vaccine failure. In this study, we analyzed the gene sequences of HV isolated from different regions of China in order to trace the molecular evolution of HV and the epidemiological trends of HFRS. A total of 16,6975 HFRS cases and 1,689 HFRS-related deaths were reported from 2004 to 2016, with the average annual incidence rate of 0.9674 per 100,000, 0.0098 per 100,000 mortality rate, and case fatality rate 0.99%. The highest number of cases were detected in 2004 (25,041), and after decreasing to the lowest numbers (8,745) in 2009, showed an incline from 2010. The incidence of HFRS is the highest in spring and winter, and three times as many men are affected as women. In addition, farmers account for the largest proportion of all cases. The main hosts of HV are Rattus norvegicus and Apodemus agrarius, and the SEOV strain is mainly found in R. norvegicus and Niviventer confucianus. Phylogenetic analysis showed that at least 10 HTNV subtypes and 6 SEOV subtypes are endemic to China. We found that the clustering pattern of M genome segments was different from that of the S segments, indicating the possibility of gene recombination across HV strains. The recent increase in the incidence of HFRS may be related to climatic factors, such as temperature, relative humidity and hours of sunshine, as well as biological factors like rodent density, virus load in rodents and genetic variation. The scope of vaccine application should be continuously expanded, and surveillance measures and prevention and control strategies should be improved to reduce HFRS infection in China.
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spelling pubmed-78869902021-02-18 Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China Wang, Qiuwei Yue, Ming Yao, Pingping Zhu, Changqiang Ai, Lele Hu, Dan Zhang, Bin Yang, Zhangnv Yang, Xiaohong Luo, Fan Wang, Chunhui Hou, Wei Tan, Weilong Front Cell Infect Microbiol Cellular and Infection Microbiology Hemorrhagic fever with renal syndrome (HFRS) is caused by hantavirus (HV) infection, and is prevalent across Europe and Asia (mainly China). The genetic variation and wide host range of the HV family may lead to vaccine failure. In this study, we analyzed the gene sequences of HV isolated from different regions of China in order to trace the molecular evolution of HV and the epidemiological trends of HFRS. A total of 16,6975 HFRS cases and 1,689 HFRS-related deaths were reported from 2004 to 2016, with the average annual incidence rate of 0.9674 per 100,000, 0.0098 per 100,000 mortality rate, and case fatality rate 0.99%. The highest number of cases were detected in 2004 (25,041), and after decreasing to the lowest numbers (8,745) in 2009, showed an incline from 2010. The incidence of HFRS is the highest in spring and winter, and three times as many men are affected as women. In addition, farmers account for the largest proportion of all cases. The main hosts of HV are Rattus norvegicus and Apodemus agrarius, and the SEOV strain is mainly found in R. norvegicus and Niviventer confucianus. Phylogenetic analysis showed that at least 10 HTNV subtypes and 6 SEOV subtypes are endemic to China. We found that the clustering pattern of M genome segments was different from that of the S segments, indicating the possibility of gene recombination across HV strains. The recent increase in the incidence of HFRS may be related to climatic factors, such as temperature, relative humidity and hours of sunshine, as well as biological factors like rodent density, virus load in rodents and genetic variation. The scope of vaccine application should be continuously expanded, and surveillance measures and prevention and control strategies should be improved to reduce HFRS infection in China. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7886990/ /pubmed/33614521 http://dx.doi.org/10.3389/fcimb.2020.584814 Text en Copyright © 2021 Wang, Yue, Yao, Zhu, Ai, Hu, Zhang, Yang, Yang, Luo, Wang, Hou and Tan http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Wang, Qiuwei
Yue, Ming
Yao, Pingping
Zhu, Changqiang
Ai, Lele
Hu, Dan
Zhang, Bin
Yang, Zhangnv
Yang, Xiaohong
Luo, Fan
Wang, Chunhui
Hou, Wei
Tan, Weilong
Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title_full Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title_fullStr Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title_full_unstemmed Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title_short Epidemic Trend and Molecular Evolution of HV Family in the Main Hantavirus Epidemic Areas From 2004 to 2016, in P.R. China
title_sort epidemic trend and molecular evolution of hv family in the main hantavirus epidemic areas from 2004 to 2016, in p.r. china
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886990/
https://www.ncbi.nlm.nih.gov/pubmed/33614521
http://dx.doi.org/10.3389/fcimb.2020.584814
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