Cargando…

An Integrated Approach Based on Network Pharmacology Combined with Experimental Verification Reveals AMPK/PI3K/Akt Signaling is an Important Way for the Anti-Type 2 Diabetic Activity of Silkworm Excrement

OBJECTIVE: This study was aimed to investigate the potential active components, targets and mechanisms of silkworm excrement (SE) in the treatment of type 2 diabetes mellitus (T(2)D) based on THE network pharmacology combined with experimental verification. METHODS: Firstly, the inhibitory effects o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan, Huxinyue, Zhang, Qing, Liu, Jia, Li, Ruolan, Peng, Wei, Wu, Chunjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887153/ https://www.ncbi.nlm.nih.gov/pubmed/33603425 http://dx.doi.org/10.2147/DMSO.S291638

Ejemplares similares

An Integrated Approach Based on Network Analysis Combined With Experimental Verification Reveals PI3K/Akt/Nrf2 Signaling Is an Important Way for the Anti-Myocardial Ischemia Activity of Yi-Qi-Tong-Luo Capsule
por: Duan, Huxinyue, et al.
Publicado: (2022)

Removal and Mechanism of Cadmium, Lead and Copper in Water by Functional Modification of Silkworm Excrement Biochar
por: Bian, Pengyang, et al.
Publicado: (2022)

Porous Fe@C Composites Derived from Silkworm Excrement for Effective Separation of Anisole Compounds
por: Wu, Yuxiang, et al.
Publicado: (2019)

Characterization of Cellulose-Degrading Bacteria Isolated from Silkworm Excrement and Optimization of Its Cellulase Production
por: Li, Hao, et al.
Publicado: (2023)

Metabolomic Analysis of Biochemical Changes in the Serum and Urine of Freund’s Adjuvant-Induced Arthritis in Rats after Treatment with Silkworm Excrement
por: Zheng, Tianyao, et al.
Publicado: (2018)

Alpiniae oxyphyllae fructus possesses neuroprotective effects on H(2)O(2) stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway
por: Li, Ruolan, et al.
Publicado: (2022)

Production of Polyhydroxyalkanoates in Unsterilized Hyper-Saline Medium by Halophiles Using Waste Silkworm Excrement as Carbon Source
por: Cai, Shuangfeng, et al.
Publicado: (2021)

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
por: Zhang, Qing, et al.
Publicado: (2021)

Nitrogen-Doped Carbon Nanoparticles Derived from Silkworm Excrement as On–Off–On Fluorescent Sensors to Detect Fe(III) and Biothiols
por: Lu, Xingchang, et al.
Publicado: (2018)

Study on the production of high 3HV content PHBV via an open fermentation with waste silkworm excrement as the carbon source by the haloarchaeon Haloferax mediterranei
por: Cai, Shuangfeng, et al.
Publicado: (2022)

Screening of PI3K-Akt-targeting Drugs for Silkworm against Bombyx mori Nucleopolyhedrovirus
por: Wang, Bingbing, et al.
Publicado: (2019)

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
por: En, Qiao, et al.
Publicado: (2021)

Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling
por: Li, Jinxiao, et al.
Publicado: (2022)

Temporal Trends in Metal Pollution: Using Bird Excrement as Indicator
por: Berglund, Åsa M. M., et al.
Publicado: (2015)

Development and in vivo Evaluation of Hydroxy-α-Sanshool Intranasal Liposomes as a Potential Remedial Treatment for Alzheimer’s Disease
por: Li, Ruolan, et al.
Publicado: (2022)

Microbial Risks Caused by Livestock Excrement: Current Research Status and Prospects
por: Abdugheni, Rashidin, et al.
Publicado: (2023)

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway
por: Song, Chao, et al.
Publicado: (2022)

The Incineration of Garbage and Excrement at Military Camps: A Report to the Health Commissioner of Buffalo
por: Bissell, W. G.
Publicado: (1900)

Attenuating lipid metabolism in atherosclerosis: The potential role of Anti-oxidative effects on low-density lipoprotein of herbal medicines
por: Duan, Huxinyue, et al.
Publicado: (2023)

Case of Obstinate Costiveness, Terminating Favourably, without the Patient Passing Any Figured Excrement
por: Rowe, Matthias
Publicado: (1818)

Revisiting the isolation source after the first discovery: Myconymphaea yatsukahoi on excrements of Lithobiomorpha (Chilopoda)
por: Takashima, Yusuke, et al.
Publicado: (2022)

Discussion on the Mechanism of Gandoufumu Decoction Attenuates Liver Damage of Wilson's Disease by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway Based on Network Pharmacology and Experimental Verification
por: Tang, Lulu, et al.
Publicado: (2023)

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
por: Bai, Xiaolin, et al.
Publicado: (2020)

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation
por: EL-MASRY, OMAR S., et al.
Publicado: (2015)

The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer
por: Dobbin, Zachary C., et al.
Publicado: (2013)

Intestinal Electric Stimulation Accelerates Whole Gut Transit and Promotes Fat Excrement in Conscious Rats
por: Sun, Ying, et al.
Publicado: (2009)

The successional trajectory of bacterial and fungal communities in soil are fabricated by yaks’ excrement contamination in plateau, China
por: Shang, Zhenda, et al.
Publicado: (2022)

High expression of TREM2 promotes EMT via the PI3K/AKT pathway in gastric cancer: bioinformatics analysis and experimental verification
por: Li, Chunmei, et al.
Publicado: (2021)

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways
por: Chiang, En-Pei Isabel, et al.
Publicado: (2014)

Differential Metabolomics and Network Pharmacology Analysis of Silkworm Biotransformation between Mulberry Leaves and Silkworm Droppings
por: Li, Mingqian, et al.
Publicado: (2021)

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
por: Duan, Fengsen, et al.
Publicado: (2020)

Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San in db/db Mice via Activation of PI3K/Akt and AMPK Pathways
por: Duan, Bailu, et al.
Publicado: (2017)

The preliminary evaluation of differential characteristics and factor evaluation of the microbial structure of rural household toilet excrement in China
por: Gao, Yi, et al.
Publicado: (2021)

Characterization of Carbapenem-Resistant Enterobacteriaceae Cultured From Retail Meat Products, Patients, and Porcine Excrement in China
por: Feng, Jie, et al.
Publicado: (2021)

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways
por: Mazibuko-Mbeje, Sithandiwe E., et al.
Publicado: (2019)

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
por: Chen, Xubo, et al.
Publicado: (2017)

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway
por: Liu, Na, et al.
Publicado: (2020)

Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatigue
por: Guo, Wei, et al.
Publicado: (2021)

Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San
por: Zhang, Shan, et al.
Publicado: (2021)

Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification
por: Chen, Wenwen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dg2iakm6ir8i7bohrigs3l62e1