Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells

Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia. Although hypoxia-inducible factors (HIFs) are known as a main regulator, the mechanisms of EPO production have not been full...

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Detalles Bibliográficos
Autores principales: Katagiri, Naoko, Hitomi, Hirofumi, Mae, Shin-Ichi, Kotaka, Maki, Lei, Li, Yamamoto, Takuya, Nishiyama, Akira, Osafune, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887226/
https://www.ncbi.nlm.nih.gov/pubmed/33594180
http://dx.doi.org/10.1038/s41598-021-83431-6

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