Rare deleterious germline variants and risk of lung cancer

Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC). Whole exome plus targeted sequencing of germline DNA was performed on 1045 LC cases and 885 controls in the discovery set. To unveil the inherited causal varian...

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Detalles Bibliográficos
Autores principales: Liu, Yanhong, Xia, Jun, McKay, James, Tsavachidis, Spiridon, Xiao, Xiangjun, Spitz, Margaret R., Cheng, Chao, Byun, Jinyoung, Hong, Wei, Li, Yafang, Zhu, Dakai, Song, Zhuoyi, Rosenberg, Susan M., Scheurer, Michael E., Kheradmand, Farrah, Pikielny, Claudio W., Lusk, Christine M., Schwartz, Ann G., Wistuba, Ignacio I., Cho, Michael H., Silverman, Edwin K., Bailey-Wilson, Joan, Pinney, Susan M., Anderson, Marshall, Kupert, Elena, Gaba, Colette, Mandal, Diptasri, You, Ming, de Andrade, Mariza, Yang, Ping, Liloglou, Triantafillos, Davies, Michael P. A., Lissowska, Jolanta, Swiatkowska, Beata, Zaridze, David, Mukeria, Anush, Janout, Vladimir, Holcatova, Ivana, Mates, Dana, Stojsic, Jelena, Scelo, Ghislaine, Brennan, Paul, Liu, Geoffrey, Field, John K., Hung, Rayjean J., Christiani, David C., Amos, Christopher I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887261/
https://www.ncbi.nlm.nih.gov/pubmed/33594163
http://dx.doi.org/10.1038/s41698-021-00146-7

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