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Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing

Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jej...

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Autores principales: Elmi, Abdi, Nasher, Fauzy, Dorrell, Nick, Wren, Brendan, Gundogdu, Ozan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887314/
https://www.ncbi.nlm.nih.gov/pubmed/33614526
http://dx.doi.org/10.3389/fcimb.2020.607704
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author Elmi, Abdi
Nasher, Fauzy
Dorrell, Nick
Wren, Brendan
Gundogdu, Ozan
author_facet Elmi, Abdi
Nasher, Fauzy
Dorrell, Nick
Wren, Brendan
Gundogdu, Ozan
author_sort Elmi, Abdi
collection PubMed
description Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jejuni have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of C. jejuni–mediated infections. We highlight, the spatial and temporal dynamics of factors that promote C. jejuni to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of C. jejuni virulence mechanisms.
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spelling pubmed-78873142021-02-18 Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing Elmi, Abdi Nasher, Fauzy Dorrell, Nick Wren, Brendan Gundogdu, Ozan Front Cell Infect Microbiol Cellular and Infection Microbiology Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jejuni have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of C. jejuni–mediated infections. We highlight, the spatial and temporal dynamics of factors that promote C. jejuni to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of C. jejuni virulence mechanisms. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7887314/ /pubmed/33614526 http://dx.doi.org/10.3389/fcimb.2020.607704 Text en Copyright © 2021 Elmi, Nasher, Dorrell, Wren and Gundogdu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Elmi, Abdi
Nasher, Fauzy
Dorrell, Nick
Wren, Brendan
Gundogdu, Ozan
Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title_full Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title_fullStr Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title_full_unstemmed Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title_short Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
title_sort revisiting campylobacter jejuni virulence and fitness factors: role in sensing, adapting, and competing
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887314/
https://www.ncbi.nlm.nih.gov/pubmed/33614526
http://dx.doi.org/10.3389/fcimb.2020.607704
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