Cargando…
Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing
Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jej...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887314/ https://www.ncbi.nlm.nih.gov/pubmed/33614526 http://dx.doi.org/10.3389/fcimb.2020.607704 |
_version_ | 1783651955450576896 |
---|---|
author | Elmi, Abdi Nasher, Fauzy Dorrell, Nick Wren, Brendan Gundogdu, Ozan |
author_facet | Elmi, Abdi Nasher, Fauzy Dorrell, Nick Wren, Brendan Gundogdu, Ozan |
author_sort | Elmi, Abdi |
collection | PubMed |
description | Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jejuni have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of C. jejuni–mediated infections. We highlight, the spatial and temporal dynamics of factors that promote C. jejuni to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of C. jejuni virulence mechanisms. |
format | Online Article Text |
id | pubmed-7887314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78873142021-02-18 Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing Elmi, Abdi Nasher, Fauzy Dorrell, Nick Wren, Brendan Gundogdu, Ozan Front Cell Infect Microbiol Cellular and Infection Microbiology Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of C. jejuni have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of C. jejuni–mediated infections. We highlight, the spatial and temporal dynamics of factors that promote C. jejuni to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of C. jejuni virulence mechanisms. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7887314/ /pubmed/33614526 http://dx.doi.org/10.3389/fcimb.2020.607704 Text en Copyright © 2021 Elmi, Nasher, Dorrell, Wren and Gundogdu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Elmi, Abdi Nasher, Fauzy Dorrell, Nick Wren, Brendan Gundogdu, Ozan Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title | Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title_full | Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title_fullStr | Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title_full_unstemmed | Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title_short | Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing |
title_sort | revisiting campylobacter jejuni virulence and fitness factors: role in sensing, adapting, and competing |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887314/ https://www.ncbi.nlm.nih.gov/pubmed/33614526 http://dx.doi.org/10.3389/fcimb.2020.607704 |
work_keys_str_mv | AT elmiabdi revisitingcampylobacterjejunivirulenceandfitnessfactorsroleinsensingadaptingandcompeting AT nasherfauzy revisitingcampylobacterjejunivirulenceandfitnessfactorsroleinsensingadaptingandcompeting AT dorrellnick revisitingcampylobacterjejunivirulenceandfitnessfactorsroleinsensingadaptingandcompeting AT wrenbrendan revisitingcampylobacterjejunivirulenceandfitnessfactorsroleinsensingadaptingandcompeting AT gundogduozan revisitingcampylobacterjejunivirulenceandfitnessfactorsroleinsensingadaptingandcompeting |