Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy

BACKGROUND: Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers to tumor immunity. However, we have previously shown that off-target delivery is a substantial problem during intratumoral injections; this can lead to diminished drug efficacy...

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Detalles Bibliográficos
Autores principales: Muñoz, Nina M., Williams, Malea, Dixon, Katherine, Dupuis, Crystal, McWatters, Amanda, Avritscher, Rony, Manrique, Soraya Zorro, McHugh, Kevin, Murthy, Ravi, Tam, Alda, Naing, Aung, Patel, Sapna P., Leach, David, Hartgerink, Jeffrey D., Young, Simon, Prakash, Punit, Hwu, Patrick, Sheth, Rahul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887346/
https://www.ncbi.nlm.nih.gov/pubmed/33589526
http://dx.doi.org/10.1136/jitc-2020-001800

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