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MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887487/ https://www.ncbi.nlm.nih.gov/pubmed/33623260 http://dx.doi.org/10.4103/aian.AIAN_500_19 |
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author | Vyas, Sameer Suthar, Renu Agarwal, Vivek Bhardwaj, Nidhi Salaria, Manila Aggarwal, Ritu Singh, Paramjeet Wickström, Ronny Singhi, Pratibha Singhi, Sunit |
author_facet | Vyas, Sameer Suthar, Renu Agarwal, Vivek Bhardwaj, Nidhi Salaria, Manila Aggarwal, Ritu Singh, Paramjeet Wickström, Ronny Singhi, Pratibha Singhi, Sunit |
author_sort | Vyas, Sameer |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world. This prospective cohort study was done with the aim of describing imaging findings in patients with Hib meningoencephalitis. MATERIALS AND METHODS: In a prospective cohort study, consecutive children admitted in the pediatric emergency unit with acute febrile encephalopathy were enrolled. The clinical details, CSF analysis, and microbiological and serological investigations were recorded on a case record proforma. Children with confirmed Hib meningoencephalitis were included in this study. Clinicoradiological features were assessed. RESULTS: A total of 16 patients with acute febrile encephalopathy, in whom CSF latex agglutination, CSF culture, or CSF multiplex PCR were positive for H. influenzae were included in this study. All these children were investigated with magnetic resonance imaging (MRI) brain. Important imaging findings were meningitis, predominantly around frontoparietal lobes (43%), cerebritis (28%), ventriculitis (14%), and subdural collections (21.5%). One patient had features consistent with acute disseminated encephalomyelitis (ADEM) while four patients had normal MRI scan. CONCLUSIONS: H. influenzae is still a common cause of meningitis in infants and children in the developing world. We have tried to study the most common MRI features associated with Hib infection to help radiologists alert the treating clinicians to further investigate these patients for appropriate prognostication. |
format | Online Article Text |
id | pubmed-7887487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-78874872021-02-22 MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children Vyas, Sameer Suthar, Renu Agarwal, Vivek Bhardwaj, Nidhi Salaria, Manila Aggarwal, Ritu Singh, Paramjeet Wickström, Ronny Singhi, Pratibha Singhi, Sunit Ann Indian Acad Neurol Original Article BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world. This prospective cohort study was done with the aim of describing imaging findings in patients with Hib meningoencephalitis. MATERIALS AND METHODS: In a prospective cohort study, consecutive children admitted in the pediatric emergency unit with acute febrile encephalopathy were enrolled. The clinical details, CSF analysis, and microbiological and serological investigations were recorded on a case record proforma. Children with confirmed Hib meningoencephalitis were included in this study. Clinicoradiological features were assessed. RESULTS: A total of 16 patients with acute febrile encephalopathy, in whom CSF latex agglutination, CSF culture, or CSF multiplex PCR were positive for H. influenzae were included in this study. All these children were investigated with magnetic resonance imaging (MRI) brain. Important imaging findings were meningitis, predominantly around frontoparietal lobes (43%), cerebritis (28%), ventriculitis (14%), and subdural collections (21.5%). One patient had features consistent with acute disseminated encephalomyelitis (ADEM) while four patients had normal MRI scan. CONCLUSIONS: H. influenzae is still a common cause of meningitis in infants and children in the developing world. We have tried to study the most common MRI features associated with Hib infection to help radiologists alert the treating clinicians to further investigate these patients for appropriate prognostication. Wolters Kluwer - Medknow 2020 2019-12-24 /pmc/articles/PMC7887487/ /pubmed/33623260 http://dx.doi.org/10.4103/aian.AIAN_500_19 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Vyas, Sameer Suthar, Renu Agarwal, Vivek Bhardwaj, Nidhi Salaria, Manila Aggarwal, Ritu Singh, Paramjeet Wickström, Ronny Singhi, Pratibha Singhi, Sunit MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title | MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title_full | MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title_fullStr | MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title_full_unstemmed | MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title_short | MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children |
title_sort | mri spectrum of haemophilus influenzae meningoencephalitis in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887487/ https://www.ncbi.nlm.nih.gov/pubmed/33623260 http://dx.doi.org/10.4103/aian.AIAN_500_19 |
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