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MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children

BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world....

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Autores principales: Vyas, Sameer, Suthar, Renu, Agarwal, Vivek, Bhardwaj, Nidhi, Salaria, Manila, Aggarwal, Ritu, Singh, Paramjeet, Wickström, Ronny, Singhi, Pratibha, Singhi, Sunit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887487/
https://www.ncbi.nlm.nih.gov/pubmed/33623260
http://dx.doi.org/10.4103/aian.AIAN_500_19
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author Vyas, Sameer
Suthar, Renu
Agarwal, Vivek
Bhardwaj, Nidhi
Salaria, Manila
Aggarwal, Ritu
Singh, Paramjeet
Wickström, Ronny
Singhi, Pratibha
Singhi, Sunit
author_facet Vyas, Sameer
Suthar, Renu
Agarwal, Vivek
Bhardwaj, Nidhi
Salaria, Manila
Aggarwal, Ritu
Singh, Paramjeet
Wickström, Ronny
Singhi, Pratibha
Singhi, Sunit
author_sort Vyas, Sameer
collection PubMed
description BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world. This prospective cohort study was done with the aim of describing imaging findings in patients with Hib meningoencephalitis. MATERIALS AND METHODS: In a prospective cohort study, consecutive children admitted in the pediatric emergency unit with acute febrile encephalopathy were enrolled. The clinical details, CSF analysis, and microbiological and serological investigations were recorded on a case record proforma. Children with confirmed Hib meningoencephalitis were included in this study. Clinicoradiological features were assessed. RESULTS: A total of 16 patients with acute febrile encephalopathy, in whom CSF latex agglutination, CSF culture, or CSF multiplex PCR were positive for H. influenzae were included in this study. All these children were investigated with magnetic resonance imaging (MRI) brain. Important imaging findings were meningitis, predominantly around frontoparietal lobes (43%), cerebritis (28%), ventriculitis (14%), and subdural collections (21.5%). One patient had features consistent with acute disseminated encephalomyelitis (ADEM) while four patients had normal MRI scan. CONCLUSIONS: H. influenzae is still a common cause of meningitis in infants and children in the developing world. We have tried to study the most common MRI features associated with Hib infection to help radiologists alert the treating clinicians to further investigate these patients for appropriate prognostication.
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spelling pubmed-78874872021-02-22 MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children Vyas, Sameer Suthar, Renu Agarwal, Vivek Bhardwaj, Nidhi Salaria, Manila Aggarwal, Ritu Singh, Paramjeet Wickström, Ronny Singhi, Pratibha Singhi, Sunit Ann Indian Acad Neurol Original Article BACKGROUND AND PURPOSE: Haemophilus influenzae type b (Hib) infection occurs mostly in children and is transmitted from person to person through the respiratory pathway. Hib strain is associated with meningitis or encephalitis. It is not an uncommon infection, particularly, in the developing world. This prospective cohort study was done with the aim of describing imaging findings in patients with Hib meningoencephalitis. MATERIALS AND METHODS: In a prospective cohort study, consecutive children admitted in the pediatric emergency unit with acute febrile encephalopathy were enrolled. The clinical details, CSF analysis, and microbiological and serological investigations were recorded on a case record proforma. Children with confirmed Hib meningoencephalitis were included in this study. Clinicoradiological features were assessed. RESULTS: A total of 16 patients with acute febrile encephalopathy, in whom CSF latex agglutination, CSF culture, or CSF multiplex PCR were positive for H. influenzae were included in this study. All these children were investigated with magnetic resonance imaging (MRI) brain. Important imaging findings were meningitis, predominantly around frontoparietal lobes (43%), cerebritis (28%), ventriculitis (14%), and subdural collections (21.5%). One patient had features consistent with acute disseminated encephalomyelitis (ADEM) while four patients had normal MRI scan. CONCLUSIONS: H. influenzae is still a common cause of meningitis in infants and children in the developing world. We have tried to study the most common MRI features associated with Hib infection to help radiologists alert the treating clinicians to further investigate these patients for appropriate prognostication. Wolters Kluwer - Medknow 2020 2019-12-24 /pmc/articles/PMC7887487/ /pubmed/33623260 http://dx.doi.org/10.4103/aian.AIAN_500_19 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Vyas, Sameer
Suthar, Renu
Agarwal, Vivek
Bhardwaj, Nidhi
Salaria, Manila
Aggarwal, Ritu
Singh, Paramjeet
Wickström, Ronny
Singhi, Pratibha
Singhi, Sunit
MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title_full MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title_fullStr MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title_full_unstemmed MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title_short MRI Spectrum of Haemophilus influenzae Meningoencephalitis in Children
title_sort mri spectrum of haemophilus influenzae meningoencephalitis in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887487/
https://www.ncbi.nlm.nih.gov/pubmed/33623260
http://dx.doi.org/10.4103/aian.AIAN_500_19
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