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Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke

BACKGROUND: Acute ischemic stroke (AIS) induces adverse effects on the cardiovascular system by affecting the autonomic nervous system (ANS). OBJECTIVES: This study aimed to determine whether the parameters of heart rate variability (HRV) and heart rate turbulence (HRT) differed in patients with AIS...

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Autores principales: Candemir, Mustafa, Onder, Halil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887491/
https://www.ncbi.nlm.nih.gov/pubmed/33623259
http://dx.doi.org/10.4103/aian.AIAN_647_19
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author Candemir, Mustafa
Onder, Halil
author_facet Candemir, Mustafa
Onder, Halil
author_sort Candemir, Mustafa
collection PubMed
description BACKGROUND: Acute ischemic stroke (AIS) induces adverse effects on the cardiovascular system by affecting the autonomic nervous system (ANS). OBJECTIVES: This study aimed to determine whether the parameters of heart rate variability (HRV) and heart rate turbulence (HRT) differed in patients with AIS as compared to that in the control group. Furthermore, we aimed to determine the differences in the involvement of the ANS between right and left hemisphere (LH) strokes. METHODS: A total of 148 [74 right hemispheres (RH) and 74 left hemispheres] patients with AIS and 80 control subjects were included in the study. The Holter device was used to obtain elcctrocardiogram readings for over 20 h from all patients. Results of HRV and HRT parameters [Tonset (TO) and Tslope (TS)] were acquired through an automatic analysis of the program. RESULTS: All HRV parameters were found to be low in patients with AIS (P < 0.05, for all parameters). TO and TS were disrupted in 99 patients with AIS (66.8%) and in 15 control subjects (18.7%) (HRT–1 and HRT–2 groups, P = <0.001). HRV parameters were detected to be similar in patients, irrespective of the left or right infarct. TO and TS were normal in 31 patients (41.9%) with left hemisphere localization and in only 18 patients (24.3%) with right hemisphere localization. CONCLUSIONS: Combined evaluation of HRV and HRT parameters may provide important information regarding the alterations in the ANS in patients with AIS. The utility of HRT in the determination of ANS alterations in patients with AIS should be investigated in larger future prospective studies.
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spelling pubmed-78874912021-02-22 Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke Candemir, Mustafa Onder, Halil Ann Indian Acad Neurol Original Article BACKGROUND: Acute ischemic stroke (AIS) induces adverse effects on the cardiovascular system by affecting the autonomic nervous system (ANS). OBJECTIVES: This study aimed to determine whether the parameters of heart rate variability (HRV) and heart rate turbulence (HRT) differed in patients with AIS as compared to that in the control group. Furthermore, we aimed to determine the differences in the involvement of the ANS between right and left hemisphere (LH) strokes. METHODS: A total of 148 [74 right hemispheres (RH) and 74 left hemispheres] patients with AIS and 80 control subjects were included in the study. The Holter device was used to obtain elcctrocardiogram readings for over 20 h from all patients. Results of HRV and HRT parameters [Tonset (TO) and Tslope (TS)] were acquired through an automatic analysis of the program. RESULTS: All HRV parameters were found to be low in patients with AIS (P < 0.05, for all parameters). TO and TS were disrupted in 99 patients with AIS (66.8%) and in 15 control subjects (18.7%) (HRT–1 and HRT–2 groups, P = <0.001). HRV parameters were detected to be similar in patients, irrespective of the left or right infarct. TO and TS were normal in 31 patients (41.9%) with left hemisphere localization and in only 18 patients (24.3%) with right hemisphere localization. CONCLUSIONS: Combined evaluation of HRV and HRT parameters may provide important information regarding the alterations in the ANS in patients with AIS. The utility of HRT in the determination of ANS alterations in patients with AIS should be investigated in larger future prospective studies. Wolters Kluwer - Medknow 2020 2020-06-29 /pmc/articles/PMC7887491/ /pubmed/33623259 http://dx.doi.org/10.4103/aian.AIAN_647_19 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Candemir, Mustafa
Onder, Halil
Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title_full Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title_fullStr Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title_full_unstemmed Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title_short Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Patients with Acute Ischemic Stroke
title_sort assessing autonomic nervous function by heart rate variability and heart rate turbulence in patients with acute ischemic stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887491/
https://www.ncbi.nlm.nih.gov/pubmed/33623259
http://dx.doi.org/10.4103/aian.AIAN_647_19
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