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The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats
Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell. Acetaminophen (N-acetyl-p-aminophenol, APAP) is a nonsteroidal anti-inflammatory drug, and can promote oxidative damage in liver and kidney ti...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887621/ https://www.ncbi.nlm.nih.gov/pubmed/32963203 http://dx.doi.org/10.1538/expanim.20-0075 |
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author | Akgun, Emrah Boyacioglu, Murat Kum, Sadiye |
author_facet | Akgun, Emrah Boyacioglu, Murat Kum, Sadiye |
author_sort | Akgun, Emrah |
collection | PubMed |
description | Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell. Acetaminophen (N-acetyl-p-aminophenol, APAP) is a nonsteroidal anti-inflammatory drug, and can promote oxidative damage in liver and kidney tissues. The aim of this study was to investigate whether folic acid has protective effects on oxidative liver and kidney injury caused by experimental APAP toxication. Forty female Sprague dawley rats were divided into 5 groups; control, APAP, FA, APAP+FA, and APAP+N-acetylcysteine (NAC) groups. APAP toxication was induced by oral gavage (3 g/kg bodyweight). FA (20 mg/kg bodyweight) and NAC (150 mg/kg bodyweight) were given by oral gavage to the specified groups. Oxidant and antioxidant parameter were determined in liver and kidney tissues. In addition, the liver and kidney tissues were histological evaluated. When compared with APAP group, superoxide dismutase (SOD) and catalase activities and glutathione levels were statistically higher, malondialdehyde (MDA) level and myeloperoxidase activity (except liver tissue) were statistically lower in both APAP+FA and APAP+NAC. Liver and kidney MDA level and kidney SOD activity were significantly lower in APAP+NAC group compared with APAP+FA group. Co-administration of NAC with APAP was found to provide protection, but hepatic cords were defective in some places and some glomerular tubules also had dilatation. Necrotic areas was reduced in the liver and the glomerular structure was in good condition in the APAP+FA group. As a result, FA might have a protective effect against APAP-induced hepato-nephrotoxicity and oxidative stress in rat. |
format | Online Article Text |
id | pubmed-7887621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78876212021-02-19 The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats Akgun, Emrah Boyacioglu, Murat Kum, Sadiye Exp Anim Original Folic acid (FA), is a group B vitamin, has high reactive oxygen radicals quenching ability, resulting in protection against oxidative damage in aerobic cell. Acetaminophen (N-acetyl-p-aminophenol, APAP) is a nonsteroidal anti-inflammatory drug, and can promote oxidative damage in liver and kidney tissues. The aim of this study was to investigate whether folic acid has protective effects on oxidative liver and kidney injury caused by experimental APAP toxication. Forty female Sprague dawley rats were divided into 5 groups; control, APAP, FA, APAP+FA, and APAP+N-acetylcysteine (NAC) groups. APAP toxication was induced by oral gavage (3 g/kg bodyweight). FA (20 mg/kg bodyweight) and NAC (150 mg/kg bodyweight) were given by oral gavage to the specified groups. Oxidant and antioxidant parameter were determined in liver and kidney tissues. In addition, the liver and kidney tissues were histological evaluated. When compared with APAP group, superoxide dismutase (SOD) and catalase activities and glutathione levels were statistically higher, malondialdehyde (MDA) level and myeloperoxidase activity (except liver tissue) were statistically lower in both APAP+FA and APAP+NAC. Liver and kidney MDA level and kidney SOD activity were significantly lower in APAP+NAC group compared with APAP+FA group. Co-administration of NAC with APAP was found to provide protection, but hepatic cords were defective in some places and some glomerular tubules also had dilatation. Necrotic areas was reduced in the liver and the glomerular structure was in good condition in the APAP+FA group. As a result, FA might have a protective effect against APAP-induced hepato-nephrotoxicity and oxidative stress in rat. Japanese Association for Laboratory Animal Science 2020-09-21 2021 /pmc/articles/PMC7887621/ /pubmed/32963203 http://dx.doi.org/10.1538/expanim.20-0075 Text en ©2021 Japanese Association for Laboratory Animal Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Akgun, Emrah Boyacioglu, Murat Kum, Sadiye The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats |
title | The potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
title_full | The potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
title_fullStr | The potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
title_full_unstemmed | The potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
title_short | The potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
title_sort | potential protective role of folic acid against acetaminophen-induced
hepatotoxicity and nephrotoxicity in rats |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887621/ https://www.ncbi.nlm.nih.gov/pubmed/32963203 http://dx.doi.org/10.1538/expanim.20-0075 |
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