Cargando…
Dose-Response Analysis of Exposure to Arsenic in Drinking Water and Risk of Skin Lesions: A Systematic Review of the Literature
BACKGROUND: Exposure to high arsenic concentrations in drinking water has been associated with skin lesions. Our goal was to conduct a systematic review of studies on skin lesions and arsenic exposure, with emphasis on results at low level of exposure. METHODS: We conducted a systematic review of st...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887677/ https://www.ncbi.nlm.nih.gov/pubmed/33633510 http://dx.doi.org/10.1177/1559325820957823 |
_version_ | 1783652032050102272 |
---|---|
author | Boffetta, Paolo Zunarelli, Carlotta Borron, Claire |
author_facet | Boffetta, Paolo Zunarelli, Carlotta Borron, Claire |
author_sort | Boffetta, Paolo |
collection | PubMed |
description | BACKGROUND: Exposure to high arsenic concentrations in drinking water has been associated with skin lesions. Our goal was to conduct a systematic review of studies on skin lesions and arsenic exposure, with emphasis on results at low level of exposure. METHODS: We conducted a systematic review of studies reporting estimates of either prevalence or risk of skin lesions associated with exposure to more than 2 levels of arsenic in drinking water. We reviewed and abstracted the relevant results, with the aim of conducting a dose-response meta-analysis. RESULTS: Nine studies of skin lesions were reviewed. Strong heterogeneity in the results did not meet the criteria for performing a meta-analysis. The relative risks for an increase of 10 μg/L arsenic in drinking water ranged from 1.002 to 1.140 (p-value of heterogeneity < 0.0001). Protection from bias and confounding was inadequate in most studies. CONCLUSION: Current studies are inadequate to conduct meta-analysis on dose-response relationship between exposure to arsenic in drinking water and skin lesions. Studies with complete exposure histories indicate skin lesions are associated with arsenic exposure in excess of 50 µg/L or higher. |
format | Online Article Text |
id | pubmed-7887677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78876772021-02-24 Dose-Response Analysis of Exposure to Arsenic in Drinking Water and Risk of Skin Lesions: A Systematic Review of the Literature Boffetta, Paolo Zunarelli, Carlotta Borron, Claire Dose Response Original Article BACKGROUND: Exposure to high arsenic concentrations in drinking water has been associated with skin lesions. Our goal was to conduct a systematic review of studies on skin lesions and arsenic exposure, with emphasis on results at low level of exposure. METHODS: We conducted a systematic review of studies reporting estimates of either prevalence or risk of skin lesions associated with exposure to more than 2 levels of arsenic in drinking water. We reviewed and abstracted the relevant results, with the aim of conducting a dose-response meta-analysis. RESULTS: Nine studies of skin lesions were reviewed. Strong heterogeneity in the results did not meet the criteria for performing a meta-analysis. The relative risks for an increase of 10 μg/L arsenic in drinking water ranged from 1.002 to 1.140 (p-value of heterogeneity < 0.0001). Protection from bias and confounding was inadequate in most studies. CONCLUSION: Current studies are inadequate to conduct meta-analysis on dose-response relationship between exposure to arsenic in drinking water and skin lesions. Studies with complete exposure histories indicate skin lesions are associated with arsenic exposure in excess of 50 µg/L or higher. SAGE Publications 2020-10-21 /pmc/articles/PMC7887677/ /pubmed/33633510 http://dx.doi.org/10.1177/1559325820957823 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Boffetta, Paolo Zunarelli, Carlotta Borron, Claire Dose-Response Analysis of Exposure to Arsenic in Drinking Water and Risk of Skin Lesions: A Systematic Review of the Literature |
title | Dose-Response Analysis of Exposure to Arsenic in Drinking Water and
Risk of Skin Lesions: A Systematic Review of the Literature |
title_full | Dose-Response Analysis of Exposure to Arsenic in Drinking Water and
Risk of Skin Lesions: A Systematic Review of the Literature |
title_fullStr | Dose-Response Analysis of Exposure to Arsenic in Drinking Water and
Risk of Skin Lesions: A Systematic Review of the Literature |
title_full_unstemmed | Dose-Response Analysis of Exposure to Arsenic in Drinking Water and
Risk of Skin Lesions: A Systematic Review of the Literature |
title_short | Dose-Response Analysis of Exposure to Arsenic in Drinking Water and
Risk of Skin Lesions: A Systematic Review of the Literature |
title_sort | dose-response analysis of exposure to arsenic in drinking water and
risk of skin lesions: a systematic review of the literature |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887677/ https://www.ncbi.nlm.nih.gov/pubmed/33633510 http://dx.doi.org/10.1177/1559325820957823 |
work_keys_str_mv | AT boffettapaolo doseresponseanalysisofexposuretoarsenicindrinkingwaterandriskofskinlesionsasystematicreviewoftheliterature AT zunarellicarlotta doseresponseanalysisofexposuretoarsenicindrinkingwaterandriskofskinlesionsasystematicreviewoftheliterature AT borronclaire doseresponseanalysisofexposuretoarsenicindrinkingwaterandriskofskinlesionsasystematicreviewoftheliterature |