Cargando…
Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assesse...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887683/ https://www.ncbi.nlm.nih.gov/pubmed/33633801 http://dx.doi.org/10.1177/1758835921992987 |
_version_ | 1783652033426882560 |
---|---|
author | Darvishian, Maryam Butt, Zahid A. Wong, Stanley Yoshida, Eric M. Khinda, Jaskaran Otterstatter, Michael Yu, Amanda Binka, Mawuena Rossi, Carmine McKee, Geoff Pearce, Margo Alvarez, Maria Wong, Jason Cook, Darrel Grennan, Troy Buxton, Jane Tyndall, Mark Woods, Ryan Krajden, Mel Bhatti, Parveen Janjua, Naveed Z. |
author_facet | Darvishian, Maryam Butt, Zahid A. Wong, Stanley Yoshida, Eric M. Khinda, Jaskaran Otterstatter, Michael Yu, Amanda Binka, Mawuena Rossi, Carmine McKee, Geoff Pearce, Margo Alvarez, Maria Wong, Jason Cook, Darrel Grennan, Troy Buxton, Jane Tyndall, Mark Woods, Ryan Krajden, Mel Bhatti, Parveen Janjua, Naveed Z. |
author_sort | Darvishian, Maryam |
collection | PubMed |
description | INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assessed the risk of colorectal, liver, and pancreatic cancers in association with HCV, HBV and HIV infection status. Using Fine and Gray adjusted proportional subdistribution hazards models, we assessed the impact of infection status on each cancer, accounting for competing mortality risk. Cancer occurrence was ascertained from the BC Cancer Registry. RESULTS: Among 658,697 individuals tested for the occurrence of all three infections, 1407 colorectal, 1294 liver, and 489 pancreatic cancers were identified. Compared to uninfected individuals, the risk of colorectal cancer was significantly elevated among those with HCV (Hazard ration [HR] 2.99; 95% confidence interval [CI] 2.55–3.51), HBV (HR 2.47; 95% CI 1.85–3.28), and HIV mono-infection (HR 2.30; 95% CI 1.47–3.59), and HCV/HIV co-infection. The risk of liver cancer was significantly elevated among HCV and HBV mono-infected and all co-infected individuals. The risk of pancreatic cancer was significantly elevated among individuals with HCV (HR 2.79; 95% CI 2.01–3.70) and HIV mono-infection (HR 2.82; 95% CI 1.39–5.71), and HCV/HBV co-infection. DISCUSSION/CONCLUSION: Compared to uninfected individuals, the risk of colorectal, pancreatic and liver cancers was elevated among those with HCV, HBV and/or HIV infection. These findings highlight the need for targeted cancer prevention and diligent clinical monitoring for hepatic and extrahepatic cancers in infected populations. |
format | Online Article Text |
id | pubmed-7887683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78876832021-02-24 Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada Darvishian, Maryam Butt, Zahid A. Wong, Stanley Yoshida, Eric M. Khinda, Jaskaran Otterstatter, Michael Yu, Amanda Binka, Mawuena Rossi, Carmine McKee, Geoff Pearce, Margo Alvarez, Maria Wong, Jason Cook, Darrel Grennan, Troy Buxton, Jane Tyndall, Mark Woods, Ryan Krajden, Mel Bhatti, Parveen Janjua, Naveed Z. Ther Adv Med Oncol Original Research INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assessed the risk of colorectal, liver, and pancreatic cancers in association with HCV, HBV and HIV infection status. Using Fine and Gray adjusted proportional subdistribution hazards models, we assessed the impact of infection status on each cancer, accounting for competing mortality risk. Cancer occurrence was ascertained from the BC Cancer Registry. RESULTS: Among 658,697 individuals tested for the occurrence of all three infections, 1407 colorectal, 1294 liver, and 489 pancreatic cancers were identified. Compared to uninfected individuals, the risk of colorectal cancer was significantly elevated among those with HCV (Hazard ration [HR] 2.99; 95% confidence interval [CI] 2.55–3.51), HBV (HR 2.47; 95% CI 1.85–3.28), and HIV mono-infection (HR 2.30; 95% CI 1.47–3.59), and HCV/HIV co-infection. The risk of liver cancer was significantly elevated among HCV and HBV mono-infected and all co-infected individuals. The risk of pancreatic cancer was significantly elevated among individuals with HCV (HR 2.79; 95% CI 2.01–3.70) and HIV mono-infection (HR 2.82; 95% CI 1.39–5.71), and HCV/HBV co-infection. DISCUSSION/CONCLUSION: Compared to uninfected individuals, the risk of colorectal, pancreatic and liver cancers was elevated among those with HCV, HBV and/or HIV infection. These findings highlight the need for targeted cancer prevention and diligent clinical monitoring for hepatic and extrahepatic cancers in infected populations. SAGE Publications 2021-02-11 /pmc/articles/PMC7887683/ /pubmed/33633801 http://dx.doi.org/10.1177/1758835921992987 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Darvishian, Maryam Butt, Zahid A. Wong, Stanley Yoshida, Eric M. Khinda, Jaskaran Otterstatter, Michael Yu, Amanda Binka, Mawuena Rossi, Carmine McKee, Geoff Pearce, Margo Alvarez, Maria Wong, Jason Cook, Darrel Grennan, Troy Buxton, Jane Tyndall, Mark Woods, Ryan Krajden, Mel Bhatti, Parveen Janjua, Naveed Z. Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title | Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title_full | Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title_fullStr | Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title_full_unstemmed | Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title_short | Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada |
title_sort | elevated risk of colorectal, liver, and pancreatic cancers among hcv, hbv and/or hiv (co)infected individuals in a population based cohort in canada |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887683/ https://www.ncbi.nlm.nih.gov/pubmed/33633801 http://dx.doi.org/10.1177/1758835921992987 |
work_keys_str_mv | AT darvishianmaryam elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT buttzahida elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT wongstanley elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT yoshidaericm elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT khindajaskaran elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT otterstattermichael elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT yuamanda elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT binkamawuena elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT rossicarmine elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT mckeegeoff elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT pearcemargo elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT alvarezmaria elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT wongjason elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT cookdarrel elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT grennantroy elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT buxtonjane elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT tyndallmark elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT woodsryan elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT krajdenmel elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT bhattiparveen elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada AT janjuanaveedz elevatedriskofcolorectalliverandpancreaticcancersamonghcvhbvandorhivcoinfectedindividualsinapopulationbasedcohortincanada |