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Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada

INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assesse...

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Autores principales: Darvishian, Maryam, Butt, Zahid A., Wong, Stanley, Yoshida, Eric M., Khinda, Jaskaran, Otterstatter, Michael, Yu, Amanda, Binka, Mawuena, Rossi, Carmine, McKee, Geoff, Pearce, Margo, Alvarez, Maria, Wong, Jason, Cook, Darrel, Grennan, Troy, Buxton, Jane, Tyndall, Mark, Woods, Ryan, Krajden, Mel, Bhatti, Parveen, Janjua, Naveed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887683/
https://www.ncbi.nlm.nih.gov/pubmed/33633801
http://dx.doi.org/10.1177/1758835921992987
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author Darvishian, Maryam
Butt, Zahid A.
Wong, Stanley
Yoshida, Eric M.
Khinda, Jaskaran
Otterstatter, Michael
Yu, Amanda
Binka, Mawuena
Rossi, Carmine
McKee, Geoff
Pearce, Margo
Alvarez, Maria
Wong, Jason
Cook, Darrel
Grennan, Troy
Buxton, Jane
Tyndall, Mark
Woods, Ryan
Krajden, Mel
Bhatti, Parveen
Janjua, Naveed Z.
author_facet Darvishian, Maryam
Butt, Zahid A.
Wong, Stanley
Yoshida, Eric M.
Khinda, Jaskaran
Otterstatter, Michael
Yu, Amanda
Binka, Mawuena
Rossi, Carmine
McKee, Geoff
Pearce, Margo
Alvarez, Maria
Wong, Jason
Cook, Darrel
Grennan, Troy
Buxton, Jane
Tyndall, Mark
Woods, Ryan
Krajden, Mel
Bhatti, Parveen
Janjua, Naveed Z.
author_sort Darvishian, Maryam
collection PubMed
description INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assessed the risk of colorectal, liver, and pancreatic cancers in association with HCV, HBV and HIV infection status. Using Fine and Gray adjusted proportional subdistribution hazards models, we assessed the impact of infection status on each cancer, accounting for competing mortality risk. Cancer occurrence was ascertained from the BC Cancer Registry. RESULTS: Among 658,697 individuals tested for the occurrence of all three infections, 1407 colorectal, 1294 liver, and 489 pancreatic cancers were identified. Compared to uninfected individuals, the risk of colorectal cancer was significantly elevated among those with HCV (Hazard ration [HR] 2.99; 95% confidence interval [CI] 2.55–3.51), HBV (HR 2.47; 95% CI 1.85–3.28), and HIV mono-infection (HR 2.30; 95% CI 1.47–3.59), and HCV/HIV co-infection. The risk of liver cancer was significantly elevated among HCV and HBV mono-infected and all co-infected individuals. The risk of pancreatic cancer was significantly elevated among individuals with HCV (HR 2.79; 95% CI 2.01–3.70) and HIV mono-infection (HR 2.82; 95% CI 1.39–5.71), and HCV/HBV co-infection. DISCUSSION/CONCLUSION: Compared to uninfected individuals, the risk of colorectal, pancreatic and liver cancers was elevated among those with HCV, HBV and/or HIV infection. These findings highlight the need for targeted cancer prevention and diligent clinical monitoring for hepatic and extrahepatic cancers in infected populations.
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spelling pubmed-78876832021-02-24 Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada Darvishian, Maryam Butt, Zahid A. Wong, Stanley Yoshida, Eric M. Khinda, Jaskaran Otterstatter, Michael Yu, Amanda Binka, Mawuena Rossi, Carmine McKee, Geoff Pearce, Margo Alvarez, Maria Wong, Jason Cook, Darrel Grennan, Troy Buxton, Jane Tyndall, Mark Woods, Ryan Krajden, Mel Bhatti, Parveen Janjua, Naveed Z. Ther Adv Med Oncol Original Research INTRODUCTION: Studies of the impact of hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV mono and co-infections on the risk of cancer, particularly extra-hepatic cancer, have been limited and inconsistent in their findings. METHODS: In the British Columbia Hepatitis Testers Cohort, we assessed the risk of colorectal, liver, and pancreatic cancers in association with HCV, HBV and HIV infection status. Using Fine and Gray adjusted proportional subdistribution hazards models, we assessed the impact of infection status on each cancer, accounting for competing mortality risk. Cancer occurrence was ascertained from the BC Cancer Registry. RESULTS: Among 658,697 individuals tested for the occurrence of all three infections, 1407 colorectal, 1294 liver, and 489 pancreatic cancers were identified. Compared to uninfected individuals, the risk of colorectal cancer was significantly elevated among those with HCV (Hazard ration [HR] 2.99; 95% confidence interval [CI] 2.55–3.51), HBV (HR 2.47; 95% CI 1.85–3.28), and HIV mono-infection (HR 2.30; 95% CI 1.47–3.59), and HCV/HIV co-infection. The risk of liver cancer was significantly elevated among HCV and HBV mono-infected and all co-infected individuals. The risk of pancreatic cancer was significantly elevated among individuals with HCV (HR 2.79; 95% CI 2.01–3.70) and HIV mono-infection (HR 2.82; 95% CI 1.39–5.71), and HCV/HBV co-infection. DISCUSSION/CONCLUSION: Compared to uninfected individuals, the risk of colorectal, pancreatic and liver cancers was elevated among those with HCV, HBV and/or HIV infection. These findings highlight the need for targeted cancer prevention and diligent clinical monitoring for hepatic and extrahepatic cancers in infected populations. SAGE Publications 2021-02-11 /pmc/articles/PMC7887683/ /pubmed/33633801 http://dx.doi.org/10.1177/1758835921992987 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Darvishian, Maryam
Butt, Zahid A.
Wong, Stanley
Yoshida, Eric M.
Khinda, Jaskaran
Otterstatter, Michael
Yu, Amanda
Binka, Mawuena
Rossi, Carmine
McKee, Geoff
Pearce, Margo
Alvarez, Maria
Wong, Jason
Cook, Darrel
Grennan, Troy
Buxton, Jane
Tyndall, Mark
Woods, Ryan
Krajden, Mel
Bhatti, Parveen
Janjua, Naveed Z.
Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title_full Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title_fullStr Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title_full_unstemmed Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title_short Elevated risk of colorectal, liver, and pancreatic cancers among HCV, HBV and/or HIV (co)infected individuals in a population based cohort in Canada
title_sort elevated risk of colorectal, liver, and pancreatic cancers among hcv, hbv and/or hiv (co)infected individuals in a population based cohort in canada
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887683/
https://www.ncbi.nlm.nih.gov/pubmed/33633801
http://dx.doi.org/10.1177/1758835921992987
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