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The Oncolytic Activity of Myxoma Virus against Soft Tissue Sarcoma Is Mediated by the Overexpression of Ribonucleotide Reductase

BACKGROUND: Myxoma virus (MYXV) is an oncolytic poxvirus that lacks the gene for 1 of the subunits of ribonucleotide reductase (RR), a crucial DNA synthesis and repair enzyme. The overexpression of RR has been implicated in the invasiveness of several cancers, including soft tissue sarcomas (STS). T...

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Detalles Bibliográficos
Autores principales:	Woo, Yanghee, Warner, Susanne G, Geha, Rula, Stanford, Marianne M, Decarolis, Penelope, Rahman, Masmudur M, Singer, Samuel, McFadden, Grant, Fong, Yuman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887694/ https://www.ncbi.nlm.nih.gov/pubmed/33633477 http://dx.doi.org/10.1177/1179554921993069

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