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Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary
BACKGROUND: The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcrani...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888072/ https://www.ncbi.nlm.nih.gov/pubmed/33596947 http://dx.doi.org/10.1186/s12992-021-00671-x |
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author | Gyamfi, Joyce Ojo, Temitope Iwelunmor, Juliet Ogedegbe, Gbenga Ryan, Nessa Diawara, Amy Nnodu, Obiageli Wonkam, Ambroise Royal, Charmaine Peprah, Emmanuel |
author_facet | Gyamfi, Joyce Ojo, Temitope Iwelunmor, Juliet Ogedegbe, Gbenga Ryan, Nessa Diawara, Amy Nnodu, Obiageli Wonkam, Ambroise Royal, Charmaine Peprah, Emmanuel |
author_sort | Gyamfi, Joyce |
collection | PubMed |
description | BACKGROUND: The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. MAIN BODY: We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. CONCLUSION: This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life. |
format | Online Article Text |
id | pubmed-7888072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78880722021-02-22 Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary Gyamfi, Joyce Ojo, Temitope Iwelunmor, Juliet Ogedegbe, Gbenga Ryan, Nessa Diawara, Amy Nnodu, Obiageli Wonkam, Ambroise Royal, Charmaine Peprah, Emmanuel Global Health Commentary BACKGROUND: The burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management. MAIN BODY: We outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa. CONCLUSION: This commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life. BioMed Central 2021-02-17 /pmc/articles/PMC7888072/ /pubmed/33596947 http://dx.doi.org/10.1186/s12992-021-00671-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Commentary Gyamfi, Joyce Ojo, Temitope Iwelunmor, Juliet Ogedegbe, Gbenga Ryan, Nessa Diawara, Amy Nnodu, Obiageli Wonkam, Ambroise Royal, Charmaine Peprah, Emmanuel Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title | Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_full | Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_fullStr | Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_full_unstemmed | Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_short | Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
title_sort | implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888072/ https://www.ncbi.nlm.nih.gov/pubmed/33596947 http://dx.doi.org/10.1186/s12992-021-00671-x |
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