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Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews
BACKGROUND: The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showing conflicting findings. The current review, therefore, sought to clarify the la...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888186/ https://www.ncbi.nlm.nih.gov/pubmed/33597037 http://dx.doi.org/10.1186/s13643-021-01606-8 |
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author | Shi, Jiyuan Zhao, Liang Gao, Ya Niu, Mingming Yan, Meili Chen, Yamin Song, Ziwei Ma, Xueni Wang, Peng Tian, Jinhui |
author_facet | Shi, Jiyuan Zhao, Liang Gao, Ya Niu, Mingming Yan, Meili Chen, Yamin Song, Ziwei Ma, Xueni Wang, Peng Tian, Jinhui |
author_sort | Shi, Jiyuan |
collection | PubMed |
description | BACKGROUND: The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showing conflicting findings. The current review, therefore, sought to clarify the latter association by assessing the methodological and reporting quality of existing systematic reviews on the subject. METHODS: We first screened PubMed, EMBASE, and Cochrane Library databases for relevant literature and subjected the resulting articles to meta-analysis. We adopted the AMSTAR-2 and PRISMA checklists for assessing methodological and reporting quality, respectively, then performed meta-analyses to determine the relationship between incidence and mortality of three types of urinary cancers with obesity and overweight. Indirect comparisons were also done across subgroups. RESULTS: All systematic reviews (SRs) were of critically low methodological quality. Seventeen SRs had minimal reporting flaws, and 11 SRs had minor reporting flaws. We found an association between obesity with an incidence of kidney (RR = 1.68, 95% CI 1.47–1.92), bladder (RR = 1.1, 95% CI 1.07–1.13), and prostate (RR = 1.02, 95% CI 0.91, 1.13) cancers. Similarly, overweight was associated with the incidence of the three types of cancer, recording RR values of 1.37 (95% CI 1.26–1.48), 1.07 (95% CI 1.03–1.1), and 1 (95% CI 0.93, 1.07) for kidney, bladder, and prostate cancers, respectively. With regard to the dose analysis, the RR of BMI (per 5 kg/m(2) increase) was associated with kidney (RR = 1.24, 95% CI 1.2–1.28), bladder (RR = 1.03, 95% CI 1.02–1.05), and prostate (RR = 1.02, 95% CI 1.01, 1.03) cancers. CONCLUSIONS: This comprehensive quantitative analysis provides an affirmation that overweight and obesity are strong risk factors for kidney cancer, owing to a strong association between them. Conversely, a weak association between overweight and obesity with bladder and prostate cancers confirms their status as mild risk factors for the 2 types of cancer. But due to the low quality of included SRs, the results need to be interpreted with caution. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019119459 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01606-8. |
format | Online Article Text |
id | pubmed-7888186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78881862021-02-22 Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews Shi, Jiyuan Zhao, Liang Gao, Ya Niu, Mingming Yan, Meili Chen, Yamin Song, Ziwei Ma, Xueni Wang, Peng Tian, Jinhui Syst Rev Research BACKGROUND: The relationship between cancer with overweight and obesity has been extensively reported. However, the association between urinary cancers with these risk factors remains unclear, with existing reports showing conflicting findings. The current review, therefore, sought to clarify the latter association by assessing the methodological and reporting quality of existing systematic reviews on the subject. METHODS: We first screened PubMed, EMBASE, and Cochrane Library databases for relevant literature and subjected the resulting articles to meta-analysis. We adopted the AMSTAR-2 and PRISMA checklists for assessing methodological and reporting quality, respectively, then performed meta-analyses to determine the relationship between incidence and mortality of three types of urinary cancers with obesity and overweight. Indirect comparisons were also done across subgroups. RESULTS: All systematic reviews (SRs) were of critically low methodological quality. Seventeen SRs had minimal reporting flaws, and 11 SRs had minor reporting flaws. We found an association between obesity with an incidence of kidney (RR = 1.68, 95% CI 1.47–1.92), bladder (RR = 1.1, 95% CI 1.07–1.13), and prostate (RR = 1.02, 95% CI 0.91, 1.13) cancers. Similarly, overweight was associated with the incidence of the three types of cancer, recording RR values of 1.37 (95% CI 1.26–1.48), 1.07 (95% CI 1.03–1.1), and 1 (95% CI 0.93, 1.07) for kidney, bladder, and prostate cancers, respectively. With regard to the dose analysis, the RR of BMI (per 5 kg/m(2) increase) was associated with kidney (RR = 1.24, 95% CI 1.2–1.28), bladder (RR = 1.03, 95% CI 1.02–1.05), and prostate (RR = 1.02, 95% CI 1.01, 1.03) cancers. CONCLUSIONS: This comprehensive quantitative analysis provides an affirmation that overweight and obesity are strong risk factors for kidney cancer, owing to a strong association between them. Conversely, a weak association between overweight and obesity with bladder and prostate cancers confirms their status as mild risk factors for the 2 types of cancer. But due to the low quality of included SRs, the results need to be interpreted with caution. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019119459 SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01606-8. BioMed Central 2021-02-17 /pmc/articles/PMC7888186/ /pubmed/33597037 http://dx.doi.org/10.1186/s13643-021-01606-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Shi, Jiyuan Zhao, Liang Gao, Ya Niu, Mingming Yan, Meili Chen, Yamin Song, Ziwei Ma, Xueni Wang, Peng Tian, Jinhui Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title | Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title_full | Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title_fullStr | Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title_full_unstemmed | Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title_short | Associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
title_sort | associating the risk of three urinary cancers with obesity and overweight: an overview with evidence mapping of systematic reviews |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888186/ https://www.ncbi.nlm.nih.gov/pubmed/33597037 http://dx.doi.org/10.1186/s13643-021-01606-8 |
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