Cargando…

Bioinformatic Analysis of the Wound Peptidome Reveals Potential Biomarkers and Antimicrobial Peptides

Wound infection is a common and serious medical condition with an unmet need for improved diagnostic tools. A peptidomic approach, aided by mass spectrometry and bioinformatics, could provide novel means of identifying new peptide biomarkers for wound healing and infection assessment. Wound fluid is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartman, Erik, Wallblom, Karl, van der Plas, Mariena J. A., Petrlova, Jitka, Cai, Jun, Saleh, Karim, Kjellström, Sven, Schmidtchen, Artur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888259/ https://www.ncbi.nlm.nih.gov/pubmed/33613550 http://dx.doi.org/10.3389/fimmu.2020.620707

Ejemplares similares

Method development and characterisation of the low-molecular-weight peptidome of human wound fluids
por: van der Plas, Mariena JA, et al.
Publicado: (2021)

Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo
por: Saravanan, Rathi, et al.
Publicado: (2017)

Peptimetric: Quantifying and Visualizing Differences in Peptidomic Data
por: Hartman, Erik, et al.
Publicado: (2021)

Selective protein aggregation confines and inhibits endotoxins in wounds: Linking host defense to amyloid formation
por: Petrlova, Jitka, et al.
Publicado: (2023)

Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
por: van der Plas, Mariena J. A., et al.
Publicado: (2016)

Study protocol for a phase 1, randomised, double-blind, placebo-controlled study to investigate the safety, tolerability and pharmacokinetics of ascending topical doses of TCP-25 applied to epidermal suction blister wounds in healthy male and female volunteers
por: Lundgren, Sigrid, et al.
Publicado: (2023)

Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products
por: Petrlova, Jitka, et al.
Publicado: (2020)

Thrombin-Derived C-Terminal Peptide Reduces Candida-Induced Inflammation and Infection In Vitro and In Vivo
por: Dahlman, Anna, et al.
Publicado: (2021)

Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides
por: Saravanan, Rathi, et al.
Publicado: (2018)

The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
por: Petruk, Ganna, et al.
Publicado: (2021)

Thrombin-Derived Host-Defense Peptides Modulate Monocyte/Macrophage Inflammatory Responses to Gram-Negative Bacteria
por: Hansen, Finja C., et al.
Publicado: (2017)

Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages
por: Hansen, Finja C., et al.
Publicado: (2021)

A Peptide of Heparin Cofactor II Inhibits Endotoxin-Mediated Shock and Invasive Pseudomonas aeruginosa Infection
por: Kalle, Martina, et al.
Publicado: (2014)

Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25
por: Petruk, Ganna, et al.
Publicado: (2020)

SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity
por: Petruk, Ganna, et al.
Publicado: (2020)

SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
por: Petrlova, Jitka, et al.
Publicado: (2022)

Editorial: Methods and applications in inflammation pharmacology
por: Schmidtchen, Artur, et al.
Publicado: (2022)

Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis
por: Kalle, Martina, et al.
Publicado: (2012)

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting
por: Saleh, Karim, et al.
Publicado: (2019)

Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments
por: Saravanan, Rathi, et al.
Publicado: (2021)

Urinary peptidomics and bioinformatics for the detection of diabetic kidney disease
por: Brondani, Letícia de Almeida, et al.
Publicado: (2020)

Publisher Correction: Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs
por: Petruk, Ganna, et al.
Publicado: (2023)

Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs
por: Petruk, Ganna, et al.
Publicado: (2023)

Development of an Experimental Ex Vivo Wound Model to Evaluate Antimicrobial Efficacy of Topical Formulations
por: Andersson, Madelene Å, et al.
Publicado: (2021)

Antimicrobial activity of a C-terminal peptide from human extracellular superoxide dismutase
por: Pasupuleti, Mukesh, et al.
Publicado: (2009)

Highly Selective End-Tagged Antimicrobial Peptides Derived from PRELP
por: Malmsten, Martin, et al.
Publicado: (2011)

Structure–function engineering of novel fish gelatin-derived multifunctional peptides using high-resolution peptidomics and bioinformatics
por: Mirzapour-Kouhdasht, Armin, et al.
Publicado: (2021)

Optimization for peptide sample preparation for urine peptidomics
por: Sigdel, Tara K, et al.
Publicado: (2014)

Peptidomic Identification of Serum Peptides Diagnosing Preeclampsia
por: Wen, Qiaojun, et al.
Publicado: (2013)

Peptidomics screening for the discovery of uterotonic plant peptides
por: Koehbach, Johannes, et al.
Publicado: (2012)

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
por: Samsudin, Firdaus, et al.
Publicado: (2022)

The molecular basis for dysfunctional bacterial lipopolysaccharide-mediated immune receptor activation by SARS-CoV-2 spike
por: Samsudin, Firdaus, et al.
Publicado: (2023)

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome
por: Dasgupta, Sayani, et al.
Publicado: (2016)

Suprabasin-derived bioactive peptides identified by plasma peptidomics
por: Taguchi, Tomomi, et al.
Publicado: (2021)

End-Tagging of Ultra-Short Antimicrobial Peptides by W/F Stretches to Facilitate Bacterial Killing
por: Pasupuleti, Mukesh, et al.
Publicado: (2009)

Novel ACE inhibitory tripeptides from ovotransferrin using bioinformatics and peptidomics approaches
por: Yu, Zhipeng, et al.
Publicado: (2019)

The plasma peptidome
por: Dufresne, Jaimie, et al.
Publicado: (2018)

Peptidomics Analysis of Virulent Peptides Involved in Streptococcus suis Pathogenesis
por: Chaiden, Chadaporn, et al.
Publicado: (2021)

Identification of potential antigenic peptides of Brucella through proteome and peptidome
por: Pei, Meijuan, et al.
Publicado: (2022)

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
por: Sonesson, Andreas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ha2fblrebms2k71flrqef72bhf