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Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
[Image: see text] Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine (LaPA complex). A preliminary investigation of the biological potential of this compound was conduct...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888264/ https://www.ncbi.nlm.nih.gov/pubmed/33528248 http://dx.doi.org/10.1021/acs.inorgchem.0c03260 |
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author | Fik-Jaskółka, Marta A. Pospieszna-Markiewicz, Izabela Roviello, Giovanni N. Kubicki, Maciej Radecka-Paryzek, Wanda Patroniak, Violetta |
author_facet | Fik-Jaskółka, Marta A. Pospieszna-Markiewicz, Izabela Roviello, Giovanni N. Kubicki, Maciej Radecka-Paryzek, Wanda Patroniak, Violetta |
author_sort | Fik-Jaskółka, Marta A. |
collection | PubMed |
description | [Image: see text] Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine (LaPA complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K(+) solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies. Moreover, LaPA induced structural changes in the Tel26 structure in a K(+)-deprived solution, suggesting that it may also lead to conformational changes in “non-G4” telomeric DNA. |
format | Online Article Text |
id | pubmed-7888264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78882642021-02-18 Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect Fik-Jaskółka, Marta A. Pospieszna-Markiewicz, Izabela Roviello, Giovanni N. Kubicki, Maciej Radecka-Paryzek, Wanda Patroniak, Violetta Inorg Chem [Image: see text] Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine (LaPA complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K(+) solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies. Moreover, LaPA induced structural changes in the Tel26 structure in a K(+)-deprived solution, suggesting that it may also lead to conformational changes in “non-G4” telomeric DNA. American Chemical Society 2021-02-02 2021-02-15 /pmc/articles/PMC7888264/ /pubmed/33528248 http://dx.doi.org/10.1021/acs.inorgchem.0c03260 Text en © 2021 American Chemical Society Made available through a Creative Commons CC-BY License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) |
spellingShingle | Fik-Jaskółka, Marta A. Pospieszna-Markiewicz, Izabela Roviello, Giovanni N. Kubicki, Maciej Radecka-Paryzek, Wanda Patroniak, Violetta Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title | Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III)
Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title_full | Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III)
Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title_fullStr | Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III)
Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title_full_unstemmed | Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III)
Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title_short | Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III)
Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect |
title_sort | synthesis and spectroscopic investigation of a hexaaza lanthanum(iii)
macrocycle with a hybrid-type g4 dna stabilizing effect |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888264/ https://www.ncbi.nlm.nih.gov/pubmed/33528248 http://dx.doi.org/10.1021/acs.inorgchem.0c03260 |
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