Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions

[Image: see text] Tuberculosis remains a leading cause of death from a single bacterial infection worldwide. Efforts to develop new treatment options call for expansion into an unexplored target space to expand the drug pipeline and bypass resistance to current antibiotics. Lipoamide dehydrogenase i...

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Detalles Bibliográficos
Autores principales: Ginn, John, Jiang, Xiuju, Sun, Shan, Michino, Mayako, Huggins, David J., Mbambo, Zodwa, Jansen, Robert, Rhee, Kyu Y., Arango, Nancy, Lima, Christopher D., Liverton, Nigel, Imaeda, Toshihiro, Okamoto, Rei, Kuroita, Takanobu, Aso, Kazuyoshi, Stamford, Andrew, Foley, Michael, Meinke, Peter T., Nathan, Carl, Bryk, Ruslana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888283/
https://www.ncbi.nlm.nih.gov/pubmed/33527832
http://dx.doi.org/10.1021/acsinfecdis.0c00788

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