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Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding
Cognitive control and decision-making rely on the interplay of medial and lateral prefrontal cortex (mPFC/lPFC), particularly for circumstances in which correct behavior requires integrating and selecting among multiple sources of interrelated information. While the interaction between mPFC and lPFC...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888340/ https://www.ncbi.nlm.nih.gov/pubmed/33613221 http://dx.doi.org/10.3389/fncom.2021.605271 |
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author | Alexander, William H. Womelsdorf, Thilo |
author_facet | Alexander, William H. Womelsdorf, Thilo |
author_sort | Alexander, William H. |
collection | PubMed |
description | Cognitive control and decision-making rely on the interplay of medial and lateral prefrontal cortex (mPFC/lPFC), particularly for circumstances in which correct behavior requires integrating and selecting among multiple sources of interrelated information. While the interaction between mPFC and lPFC is generally acknowledged as a crucial circuit in adaptive behavior, the nature of this interaction remains open to debate, with various proposals suggesting complementary roles in (i) signaling the need for and implementing control, (ii) identifying and selecting appropriate behavioral policies from a candidate set, and (iii) constructing behavioral schemata for performance of structured tasks. Although these proposed roles capture salient aspects of conjoint mPFC/lPFC function, none are sufficiently well-specified to provide a detailed account of the continuous interaction of the two regions during ongoing behavior. A recent computational model of mPFC and lPFC, the Hierarchical Error Representation (HER) model, places the regions within the framework of hierarchical predictive coding, and suggests how they interact during behavioral periods preceding and following salient events. In this manuscript, we extend the HER model to incorporate real-time temporal dynamics and demonstrate how the extended model is able to capture single-unit neurophysiological, behavioral, and network effects previously reported in the literature. Our results add to the wide range of results that can be accounted for by the HER model, and provide further evidence for predictive coding as a unifying framework for understanding PFC function and organization. |
format | Online Article Text |
id | pubmed-7888340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78883402021-02-18 Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding Alexander, William H. Womelsdorf, Thilo Front Comput Neurosci Neuroscience Cognitive control and decision-making rely on the interplay of medial and lateral prefrontal cortex (mPFC/lPFC), particularly for circumstances in which correct behavior requires integrating and selecting among multiple sources of interrelated information. While the interaction between mPFC and lPFC is generally acknowledged as a crucial circuit in adaptive behavior, the nature of this interaction remains open to debate, with various proposals suggesting complementary roles in (i) signaling the need for and implementing control, (ii) identifying and selecting appropriate behavioral policies from a candidate set, and (iii) constructing behavioral schemata for performance of structured tasks. Although these proposed roles capture salient aspects of conjoint mPFC/lPFC function, none are sufficiently well-specified to provide a detailed account of the continuous interaction of the two regions during ongoing behavior. A recent computational model of mPFC and lPFC, the Hierarchical Error Representation (HER) model, places the regions within the framework of hierarchical predictive coding, and suggests how they interact during behavioral periods preceding and following salient events. In this manuscript, we extend the HER model to incorporate real-time temporal dynamics and demonstrate how the extended model is able to capture single-unit neurophysiological, behavioral, and network effects previously reported in the literature. Our results add to the wide range of results that can be accounted for by the HER model, and provide further evidence for predictive coding as a unifying framework for understanding PFC function and organization. Frontiers Media S.A. 2021-02-03 /pmc/articles/PMC7888340/ /pubmed/33613221 http://dx.doi.org/10.3389/fncom.2021.605271 Text en Copyright © 2021 Alexander and Womelsdorf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Alexander, William H. Womelsdorf, Thilo Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title | Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title_full | Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title_fullStr | Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title_full_unstemmed | Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title_short | Interactions of Medial and Lateral Prefrontal Cortex in Hierarchical Predictive Coding |
title_sort | interactions of medial and lateral prefrontal cortex in hierarchical predictive coding |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888340/ https://www.ncbi.nlm.nih.gov/pubmed/33613221 http://dx.doi.org/10.3389/fncom.2021.605271 |
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