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Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) encodes an enzyme that catalyzes de novo purine biosynthesis. Although PAICS has been implicated as a potential therapeutic target in several cancers, its clinical and prognostic significance...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Yusuke, Kumamoto, Kensuke, Okayama, Hirokazu, Matsumoto, Takuro, Nakano, Hiroshi, Saito, Katsuharu, Matsumoto, Yoshiko, Endo, Eisei, Kanke, Yasuyuki, Watanabe, Yohei, Onozawa, Hisashi, Fujita, Shotaro, Sakamoto, Wataru, Saito, Motonobu, Momma, Tomoyuki, Takenoshita, Seiichi, Kono, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888640/ https://www.ncbi.nlm.nih.gov/pubmed/33596246 http://dx.doi.org/10.1371/journal.pone.0247169

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