An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

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The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, because of close similarity with the natural receptor, hold out the promise of...

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Detalles Bibliográficos
Autores principales: Chan, Kui K., Tan, Timothy J. C., Narayanan, Krishna K., Procko, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888922/
https://www.ncbi.nlm.nih.gov/pubmed/33597251
http://dx.doi.org/10.1126/sciadv.abf1738

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