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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

The kinase PDK1 is a crucial regulator for immune cell development by connecting PI3K to downstream AKT signaling. However, the roles of PDK1 in CD4(+) T cell differentiation, especially in T follicular helper (Tfh) cell, remain obscure. Here we reported PDK1 intrinsically promotes the Tfh cell diff...

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Detalles Bibliográficos
Autores principales:	Sun, Zhen, Yao, Yingpeng, You, Menghao, Liu, Jingjing, Guo, Wenhui, Qi, Zhihong, Wang, Zhao, Wang, Fang, Yuan, Weiping, Yu, Shuyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889074/ https://www.ncbi.nlm.nih.gov/pubmed/33595435 http://dx.doi.org/10.7554/eLife.61406

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