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The expanding scope of amyloid signalling

Formation of higher-order supramolecular complexes has emerged as a common principle underlying activity of a number of immune and regulated cell-death signalling pathways in animals, plants and fungi. Some of these signalosomes employ functional amyloid motifs in their assembly process. The descrip...

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Detalles Bibliográficos
Autores principales: Daskalov, Asen, Saupe, Sven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889193/
https://www.ncbi.nlm.nih.gov/pubmed/33573441
http://dx.doi.org/10.1080/19336896.2021.1874791
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author Daskalov, Asen
Saupe, Sven J.
author_facet Daskalov, Asen
Saupe, Sven J.
author_sort Daskalov, Asen
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description Formation of higher-order supramolecular complexes has emerged as a common principle underlying activity of a number of immune and regulated cell-death signalling pathways in animals, plants and fungi. Some of these signalosomes employ functional amyloid motifs in their assembly process. The description of such systems in fungi finds its origin in earlier studies on a fungal prion termed [Het-s], originally identified as a non-Mendelian cytoplasmic infectious element. Janine Beisson has been a key contributor to such early studies. Recent work on this and related systems offers a more integrated view framing this prion in a broader picture including related signalling systems described in animals. We propose here an auto-commentary centred on three recent studies on amyloid signalling in microbes. Collectively, these studies increase our understanding of fold conservation in functional amyloids and the structural basis of seeding, highlight the relation of fungal amyloid motifs to mammalian RHIM (RIP homotypic interaction motif) and expand the concept of Nod-like receptor-based amyloid signalosomes to the prokaryote reign.
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spelling pubmed-78891932021-02-23 The expanding scope of amyloid signalling Daskalov, Asen Saupe, Sven J. Prion Extra-View Formation of higher-order supramolecular complexes has emerged as a common principle underlying activity of a number of immune and regulated cell-death signalling pathways in animals, plants and fungi. Some of these signalosomes employ functional amyloid motifs in their assembly process. The description of such systems in fungi finds its origin in earlier studies on a fungal prion termed [Het-s], originally identified as a non-Mendelian cytoplasmic infectious element. Janine Beisson has been a key contributor to such early studies. Recent work on this and related systems offers a more integrated view framing this prion in a broader picture including related signalling systems described in animals. We propose here an auto-commentary centred on three recent studies on amyloid signalling in microbes. Collectively, these studies increase our understanding of fold conservation in functional amyloids and the structural basis of seeding, highlight the relation of fungal amyloid motifs to mammalian RHIM (RIP homotypic interaction motif) and expand the concept of Nod-like receptor-based amyloid signalosomes to the prokaryote reign. Taylor & Francis 2021-02-12 /pmc/articles/PMC7889193/ /pubmed/33573441 http://dx.doi.org/10.1080/19336896.2021.1874791 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Extra-View
Daskalov, Asen
Saupe, Sven J.
The expanding scope of amyloid signalling
title The expanding scope of amyloid signalling
title_full The expanding scope of amyloid signalling
title_fullStr The expanding scope of amyloid signalling
title_full_unstemmed The expanding scope of amyloid signalling
title_short The expanding scope of amyloid signalling
title_sort expanding scope of amyloid signalling
topic Extra-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889193/
https://www.ncbi.nlm.nih.gov/pubmed/33573441
http://dx.doi.org/10.1080/19336896.2021.1874791
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