Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fevereiro, João, Fraga, Alexandra G., Capela, Carlos, Sopoh, Ghislain E., Dossou, Ange, Ayelo, Gilbert Adjimon, Peixoto, Maria João, Cunha, Cristina, Carvalho, Agostinho, Rodrigues, Fernando, Pedrosa, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889264/
https://www.ncbi.nlm.nih.gov/pubmed/33467983
http://dx.doi.org/10.1080/22221751.2021.1878936
Descripción
Sumario:Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.

Ejemplares similares