Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Fevereiro, João, Fraga, Alexandra G., Capela, Carlos, Sopoh, Ghislain E., Dossou, Ange, Ayelo, Gilbert Adjimon, Peixoto, Maria João, Cunha, Cristina, Carvalho, Agostinho, Rodrigues, Fernando, Pedrosa, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889264/
https://www.ncbi.nlm.nih.gov/pubmed/33467983
http://dx.doi.org/10.1080/22221751.2021.1878936
_version_ 1783652273215242240
author Fevereiro, João
Fraga, Alexandra G.
Capela, Carlos
Sopoh, Ghislain E.
Dossou, Ange
Ayelo, Gilbert Adjimon
Peixoto, Maria João
Cunha, Cristina
Carvalho, Agostinho
Rodrigues, Fernando
Pedrosa, Jorge
author_facet Fevereiro, João
Fraga, Alexandra G.
Capela, Carlos
Sopoh, Ghislain E.
Dossou, Ange
Ayelo, Gilbert Adjimon
Peixoto, Maria João
Cunha, Cristina
Carvalho, Agostinho
Rodrigues, Fernando
Pedrosa, Jorge
author_sort Fevereiro, João
collection PubMed
description Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.
format Online
Article
Text
id pubmed-7889264
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-78892642021-02-23 Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer Fevereiro, João Fraga, Alexandra G. Capela, Carlos Sopoh, Ghislain E. Dossou, Ange Ayelo, Gilbert Adjimon Peixoto, Maria João Cunha, Cristina Carvalho, Agostinho Rodrigues, Fernando Pedrosa, Jorge Emerg Microbes Infect Letter Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients. Taylor & Francis 2021-02-11 /pmc/articles/PMC7889264/ /pubmed/33467983 http://dx.doi.org/10.1080/22221751.2021.1878936 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Fevereiro, João
Fraga, Alexandra G.
Capela, Carlos
Sopoh, Ghislain E.
Dossou, Ange
Ayelo, Gilbert Adjimon
Peixoto, Maria João
Cunha, Cristina
Carvalho, Agostinho
Rodrigues, Fernando
Pedrosa, Jorge
Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title_full Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title_fullStr Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title_full_unstemmed Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title_short Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
title_sort genetic variants in human bcl2l11 (bim) are associated with ulcerative forms of buruli ulcer
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889264/
https://www.ncbi.nlm.nih.gov/pubmed/33467983
http://dx.doi.org/10.1080/22221751.2021.1878936
work_keys_str_mv AT fevereirojoao geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT fragaalexandrag geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT capelacarlos geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT sopohghislaine geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT dossouange geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT ayelogilbertadjimon geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT peixotomariajoao geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT cunhacristina geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT carvalhoagostinho geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT rodriguesfernando geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer
AT pedrosajorge geneticvariantsinhumanbcl2l11bimareassociatedwithulcerativeformsofburuliulcer

Ejemplares similares