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Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment

Leukocytes, including macrophages and T cells, represent key players in the human immune system, which plays a considerable role in the development and progression of tumors by immune surveillance or immune escape. Boosting the recruitment of leukocytes into the tumor microenvironment and promoting...

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Autores principales: Shen, Lesang, Zhou, Yunxiang, He, Haifei, Chen, Wuzhen, Lenahan, Cameron, Li, Xiaoyi, Deng, Yongchuan, Shao, Anwen, Huang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889336/
https://www.ncbi.nlm.nih.gov/pubmed/33628389
http://dx.doi.org/10.1155/2021/8865791
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author Shen, Lesang
Zhou, Yunxiang
He, Haifei
Chen, Wuzhen
Lenahan, Cameron
Li, Xiaoyi
Deng, Yongchuan
Shao, Anwen
Huang, Jian
author_facet Shen, Lesang
Zhou, Yunxiang
He, Haifei
Chen, Wuzhen
Lenahan, Cameron
Li, Xiaoyi
Deng, Yongchuan
Shao, Anwen
Huang, Jian
author_sort Shen, Lesang
collection PubMed
description Leukocytes, including macrophages and T cells, represent key players in the human immune system, which plays a considerable role in the development and progression of tumors by immune surveillance or immune escape. Boosting the recruitment of leukocytes into the tumor microenvironment and promoting their antitumor responses have been hot areas of research in recent years. Although immunotherapy has manifested a certain level of success in some malignancies, the overall effectiveness is far from satisfactory. Iron is an essential trace element required in multiple, normal cellular processes, such as DNA synthesis and repair, cellular respiration, metabolism, and signaling, while dysregulated iron metabolism has been declared one of the metabolic hallmarks of malignant cancer cells. Furthermore, iron is implicated in the modulation of innate and adaptive immune responses, and elucidating the targeted regulation of iron metabolism may have the potential to benefit antitumor immunity and cancer treatment. In the present review, we briefly summarize the roles of leukocytes and iron metabolism in tumorigenesis, as well as their crosstalk in the tumor microenvironment. The combination of immunotherapy with targeted regulation of iron and iron-dependent regulated cell death (ferroptosis) may be a focus of future research.
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spelling pubmed-78893362021-02-23 Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment Shen, Lesang Zhou, Yunxiang He, Haifei Chen, Wuzhen Lenahan, Cameron Li, Xiaoyi Deng, Yongchuan Shao, Anwen Huang, Jian Oxid Med Cell Longev Review Article Leukocytes, including macrophages and T cells, represent key players in the human immune system, which plays a considerable role in the development and progression of tumors by immune surveillance or immune escape. Boosting the recruitment of leukocytes into the tumor microenvironment and promoting their antitumor responses have been hot areas of research in recent years. Although immunotherapy has manifested a certain level of success in some malignancies, the overall effectiveness is far from satisfactory. Iron is an essential trace element required in multiple, normal cellular processes, such as DNA synthesis and repair, cellular respiration, metabolism, and signaling, while dysregulated iron metabolism has been declared one of the metabolic hallmarks of malignant cancer cells. Furthermore, iron is implicated in the modulation of innate and adaptive immune responses, and elucidating the targeted regulation of iron metabolism may have the potential to benefit antitumor immunity and cancer treatment. In the present review, we briefly summarize the roles of leukocytes and iron metabolism in tumorigenesis, as well as their crosstalk in the tumor microenvironment. The combination of immunotherapy with targeted regulation of iron and iron-dependent regulated cell death (ferroptosis) may be a focus of future research. Hindawi 2021-02-02 /pmc/articles/PMC7889336/ /pubmed/33628389 http://dx.doi.org/10.1155/2021/8865791 Text en Copyright © 2021 Lesang Shen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shen, Lesang
Zhou, Yunxiang
He, Haifei
Chen, Wuzhen
Lenahan, Cameron
Li, Xiaoyi
Deng, Yongchuan
Shao, Anwen
Huang, Jian
Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title_full Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title_fullStr Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title_full_unstemmed Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title_short Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
title_sort crosstalk between macrophages, t cells, and iron metabolism in tumor microenvironment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889336/
https://www.ncbi.nlm.nih.gov/pubmed/33628389
http://dx.doi.org/10.1155/2021/8865791
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